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Table 3 Univariate and multivariate analyses of variables associated with BCSS in TNBC (N=101)

From: Prognostic significance of tumor-infiltrating CD8+ and FOXP3+ lymphocytes in residual tumors and alterations in these parameters after neoadjuvant chemotherapy in triple-negative breast cancer: a retrospective multicenter study

Variables Univariate analysis Multivariate analysis
  HR 95 % CI P value HR 95 % CI P value
Age (<50 vs. 50<) 1.85 0.877–3.944 0.1055    
Residual tumor size (>2.0 cm vs. <2.0 cm) 2.89 1.354–6.520 0.0059* 1.37 0.593–3.332 0.4637
Nodal status after NAC (positive vs. negative) 4.83 2.144–12.29 <0.0001* 3.76 1.574–10.02 0.0024*
Grade (III vs. I, II) 1.45 0.460–2.173 0.4014    
Basal-like vs. non basal-like 1.56 0.721–3.635 0.2634    
Ki-67 LI (high vs. low) 1.78 0.839–3.935 0.1329    
Unstained TILs (low vs. high) 2.38 0.709–14.77 0.1815    
CD8 (low vs. high) 4.75 2.106–12.12 0.0001* 3.59 1.499–9.581 0.0036*
CD8 (as a continuous variable)a 1.01b 1.004–1.016 0.0007* 1.01b 1.001–1.015 0.0152*
FOXP3 (low vs. high) 1.68 0.795–3.699 0.1751    
FOXP3 (as a continuous variable)a 1.00b 0.998–1.013 0.1412    
CD8/FOXP3 (low vs. high) 2.53 1.128–6.436 0.0233* 1.28 0.526–3.453 0.5932
CD8/FOXP3 (as a continuous variable)a 1.25b 1.048–1.649 0.0077* 1.11b 0.953–1.397 0.2115
  1. Multivariate cox regression analyses were performed for all potential variables that were significantly associated with survival in univariate analysis
  2. BCSS breast cancer-specific survival, HR hazard ratio, CI confidence interval, NAC neoadjuvant chemotherapy, LI labeling index, TIL tumor-infiltrating lymphocyte
  3. *The P value is significant
  4. aAnalyses were performed by the continuous variables
  5. bThe HRs of the continuous variables are shown as a unit ratio