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Fig. 5 | Breast Cancer Research

Fig. 5

From: Expression profiling of in vivo ductal carcinoma in situ progression models identified B cell lymphoma-9 as a molecular driver of breast cancer invasion

Fig. 5

BCL9-KD inhibits invasion in DCIS cell line mouse intraductal xenograft model (MIND) xenografts. a Immunofluorescent (IF) staining of BCL9 (red), K5/K19 (green), and 4′,6-diamidino-2-phenylindole (DAPI) (blue) in DCIS.COM (left) and SUM225 (right), control and BCL9-KD MIND xenografts at 10 and 14 weeks post-intraductal injection, respectively. b IF staining of K5 (red), smooth muscle actin (SMA) (green), and DAPI in DCIS.COM cells demonstrating how distance of invasion was measured. Scale bars = 50 μm, × 40 magnification. c Bar graphs represent the maximum distance of invasion and number of invasive lesions in control and BCL9-KD for DCIS.COM and SUM225 MIND xenografts. Data represent the mean ± standard error of the mean (n = 4, *p <0.05)

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Breast Cancer Research

ISSN: 1465-542X

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