Risk factor | Standard risk factors and BMI | Standard risk factors and BMI plus area percent density | Standard risk factors and BMI plus area and volumetric density with feature selection | ||||||
---|---|---|---|---|---|---|---|---|---|
Odds ratio | P value | AUC | Odds ratio | P value | AUC | Odds ratio | P value | AUC | |
Demographics | 0.80 (0.75–0.85) | 0.85a (0.81–0.90) | 0.86a (0.82–0.90) | ||||||
Age | 0.98 | 0.75 | 1.12 | 0.21 | 1.11 | 0.24 | |||
(0.83–1.14) | (0.94–1.33) | (0.93–1.32) | |||||||
Age at menarche | 0.73 | 0.22 | 0.74 | 0.26 | 0.79 | 0.37 | |||
(0.44–1.20) | (0.44–1.24) | (0.47–1.32) | |||||||
Number of benign biopsies | 1.19 | 0.39 | 1.10 | 0.67 | 1.07 | 0.75 | |||
(0.80–1.78) | (0.71–1.69) | (0.70–1.65) | |||||||
First-degree family history | 0.89 | 0.68 | 0.78 | 0.42 | 0.74 | 0.33 | |||
(0.51–1.56) | (0.43–1.43) | (0.40–1.35) | |||||||
Parity | |||||||||
Nulliparous | 1 | – | 1 | – | 1 | – | |||
(N/A) | (N/A) | (N/A) | |||||||
Prior to age 30 years | 2.08 | 0.04 | 2.46 | 0.02 | 2.88 | 0.006 | |||
(1.03–4.17) | (1.17–5.19) | (1.34–6.18) | |||||||
Age 30 years or older | 2.00 | 0.09 | 2.03 | 0.09 | 2.27 | 0.06 | |||
(0.91–4.38) | (0.89–4.66) | (0.97–5.31) | |||||||
Race | |||||||||
Caucasian | 1 | – | 1 | – | 1 | – | |||
(N/A) | (N/A) | (N/A) | |||||||
African-American | 0.30 | 0.001 | 0.29 | 0.004 | 0.24 | 0.001 | |||
(0.14–0.63) | (0.13–0.64) | (0.11–0.54) | |||||||
Asian | 0.58 | 0.55 | 0.71 | 0.72 | 0.73 | 0.74 | |||
(0.10–3.37) | (0.11–4.72) | (0.11–4.66) | |||||||
Other | 0.73 | 0.71 | 0.82 | 0.82 | 0.99 | 0.99 | |||
(0.15–3.69) | (0.14–4.66) | (0.18–5.46) | |||||||
BMI | 3.43 | <0.001 | 5.10 | <0.001 | 3.93 | <0.001 | |||
(2.33–5.04) | (3.07–8.45) | (2.47–6.26) | |||||||
Continuous density estimates | |||||||||
LIBRA: absolute dense area | – | – | – | – | 2.18 | <0.001 | |||
(1.53–3.11) | |||||||||
LIBRA: area percent density | – | – | 2.64 | <0.001 | – | – | |||
(1.79–3.89) | |||||||||
Quantra: absolute dense volume | – | – | – | – | – | – | |||
Quantra: volume percent density | – | – | – | – | 1.47 | 0.06 | |||
(0.99–2.19) |