Risk factor | Standard risk factors only | Gail risk factors plus area percent density | Gail risk factors plus area and volumetric density with feature selection | ||||||
---|---|---|---|---|---|---|---|---|---|
Odds ratio | P value | AUC | Odds ratio | P value | AUC | Odds ratio | P value | AUC | |
Demographics | 0.64 (0.58–0.71) | 0.68a (0.62–0.74) | 0.77a (0.71–0.82) | ||||||
Age | 0.96 | 0. 59 | 1.02 | 0.73 | 1.06 | 0.41 | |||
(0.84–1.10) | (0.90–1.17) | (0.92–1.23) | |||||||
Age at menarche | 0.56 | 0.01 | 0.54 | 0.008 | 0.64 | 0.06 | |||
(0.36–0.89) | (0.34–0.85) | (0.40–1.02) | |||||||
Number of benign biopsies | 1.08 | 0.67 | 1.02 | 0.94 | 0.97 | 0.90 | |||
(0.75–1.55) | (0.70–1.47) | (0.65–1.45) | |||||||
First-degree family history | 0.91 | 0.72 | 0.83 | 0.49 | 0.72 | 0.26 | |||
(0.54–1.52) | (0.49–1.40) | (0.42–1.26) | |||||||
Parity | – | – | |||||||
Nulliparous | 1 | – | 1 | – | 1 | – | |||
(N/A) | (N/A) | (N/A) | |||||||
Prior to age 30 years | 2.22 | 0.01 | 2.49 | 0.005 | 3.33 | 0.001 | |||
(1.18–4.16) | (1.31–4.73) | (1.67–6.64) | |||||||
Age 30 years or older | 2.01 | 0.05 | 2.12 | 0.04 | 2.46 | 0.02 | |||
(0.99–4.08) | (1.03–4.35) | (0.–4.08) | |||||||
Race | |||||||||
Caucasian | 1 | – | 1 | – | 1 | – | |||
(N/A) | (N/A) | (N/A) | |||||||
African-American | 0.54 | 0.04 | 0.58 | 0.08 | 0.39 | 0.005 | |||
(0.30–0.97) | (0.32–1.06) | (0.21–0.75) | |||||||
Asian | 0.45 | 0.33 | 0.50 | 0.40 | 0.55 | 0.49 | |||
(0.09–2.19) | (0.10–2.52) | (0.10–2.98) | |||||||
Other | 0.80 | 0.76 | 0.90 | 0.88 | 1.04 | 0.96 | |||
(0.20–3.27) | (0.21–3.83) | (0.23–4.74) | |||||||
Continuous density estimates | |||||||||
LIBRA: absolute dense area | – | – | – | – | 1.84 | <0.001 | |||
(1.32–2.54) | |||||||||
LIBRA: area percent density | – | – | 1.64 | <0.001 | – | – | |||
(1.25–2.14) | |||||||||
Quantra: absolute dense volume | – | – | – | – | 1.67 | 0.003 | |||
(1.19–2.34) | |||||||||
Quantra: volume percent density | – | – | – | – | – | – |