Table 3 Unadjusted odds ratios per standard deviation increase in the log-transformed LIBRA and Quantra density measures (per-category in the ordinal BI-RADS density measure), P values, and discriminatory capacity (AUC) of the continuous and categorical BI-RADS breast density estimates

LIBRA: absolute dense area, cm²

2.23

<0.001

0.71^a

1

3.33

5.81

8.38

(Continuous)

(1.72–2.88)

(0.65–0.76)

(N/A - reference)

(2.25–4.88)

(3.28–10.17)

(4.21–16.52)

LIBRA: area percent density, PD %

1.50

<0.001

0.60^a

1

1.66

2.17

2.71

(Continuous)

(1.18–1.91)

(0.54–0.66)

(N/A - reference)

(1.23–2.24)

(1.37–3.44)

(1.5–4.91)

Quantra: absolute dense volume, cm³

2.04

<0.001

0.68^a

1

2.41

4.05

5.87

(Continuous)

(1.58–2.63)

(0.62–0.74)

(N/A - reference)

(1.76–3.3)

(2.45–6.66)

(3.11–11.03)

Quantra: volume percent density, VD %

1.47

0.002

0.59^a

1

1.65

2.09

2.48

(Continuous)

(1.15–1.89)

(0.53–0.65)

(N/A - reference)

(1.2–2.28)

(1.31–3.37)

(1.39–4.48)

Radiologist’s BI-RADS density (ordinal categories)

1.02 (0.71–1.45)

0.93

0.50 (0.44–0.55)

Predominantly fatty

Scattered fibroglandular densities

Heterogeneously dense

Extremely dense

1

1.02

1.03

1.05

(N/A - reference)

(0.71–1.45)

(0.51–2.10)

(0.36–3.04)