Table 3 Association between mammographic density and current use of menopausal hormone therapy stratified by genotypes of ten SNPs showing the lowest P values for interaction

T/T (2000)

T/G (3167)

G/G (1131)

rs9358531

Imputed

6

6.5 kb 5′ of PRL

PD

0.23 (0.08, 0.38)

2.5 × 10⁻⁰³

0.46 (0.34, 0.58)

5.1 × 10⁻¹⁴

0.69 (0.49, 0.89)

1.4 × 10⁻¹¹

0.0004

DA

0.38 (0.18, 0.58)

2.1 × 10⁻⁰⁴

0.6 (0.44, 0.76)

1.2 × 10⁻¹³

0.85 (0.59, 1.12)

2.7 × 10⁻¹⁰

0.008

NDA

−0.17 (−0.39, 0.05)

1.4 × 10⁻⁰¹

−0.29 (−0.47, −0.12)

1.2 × 10⁻⁰³

−0.58 (−0.87, −0.29)

1.0 × 10⁻⁰⁴

0.02

G/G (2138)

G/A (3142)

A/A (1018)

rs9356811

Imputed

6

5.2 kb 5′ of PRL

PD

0.24 (0.1, 0.39)

1.1 × 10⁻⁰³

0.48 (0.36, 0.6)

1.3 × 10⁻¹⁴

0.69 (0.48, 0.9)

1.5 × 10⁻¹⁰

0.0004

DA

0.39 (0.2, 0.59)

6.6 × 10⁻⁰⁵

0.6 (0.44, 0.76)

1.9 × 10⁻¹³

0.89 (0.61, 1.17)

4.6 × 10⁻¹⁰

0.005

NDA

−0.17 (−0.38, 0.05)

1.2 × 10⁻⁰¹

−0.33 (−0.51, −0.15)

2.5 × 10⁻⁰⁴

−0.51 (−0.82, −0.2)

1.1 × 10⁻⁰³

0.05

C/C (2158)

C/T (3124)

T/T (1016)

rs10946546

Imputed

6

17 kb 5′ of PRL

PD

0.22 (0.07, 0.37)

3.2 × 10⁻⁰³

0.51 (0.39, 0.63)

2.2 × 10⁻¹⁶

0.63 (0.42, 0.84)

3.0 × 10⁻⁰⁹

0.0004

DA

0.39 (0.19, 0.58)

9.0 × 10⁻⁰⁵

0.64 (0.48, 0.8)

4.8 × 10⁻¹⁵

0.77 (0.49, 1.05)

4.9 × 10⁻⁰⁸

0.02

NDA

−0.11 (−0.32, 0.1)

3.1 × 10⁻⁰¹

−0.37 (−0.55, −0.2)

3.4 × 10⁻⁰⁵

−0.49 (−0.8, −0.19)

1.5 × 10⁻⁰³

0.01

T/T (2230)

T/C (3093)

C/C (975)

rs9393273

Imputed

6

8.1 kb 5′ of PRL

PD

0.24 (0.1, 0.39)

7.8 × 10⁻⁰⁴

0.49 (0.37, 0.61)

4.8 × 10⁻¹⁵

0.68 (0.47, 0.89)

5.0 × 10⁻¹⁰

0.0005

DA

0.4 (0.21, 0.59)

3.6 × 10⁻⁰⁵

0.62 (0.46, 0.78)

8.5 × 10⁻¹⁴

0.86 (0.58, 1.15)

2.4 × 10⁻⁰⁹

0.01

NDA

−0.16 (−0.37, 0.05)

1.3 × 10⁻⁰¹

−0.33 (−0.51, −0.16)

2.4 × 10⁻⁰⁴

−0.54 (−0.85, −0.23)

6.9 × 10⁻⁰⁴

0.03

A/A (2079)

A/G (3154)

G/G (1065)

rs12525289

Imputed

6

9.9 kb 5′ of PRL

PD

0.24 (0.09, 0.39)

1.5 × 10⁻⁰³

0.47 (0.35, 0.59)

2.0 × 10⁻¹⁴

0.68 (0.47, 0.88)

7.8 × 10⁻¹¹

0.0005

DA

0.4 (0.2, 0.59)

7.3 × 10⁻⁰⁵

0.59 (0.43, 0.76)

4.3 × 10⁻¹³

0.88 (0.61, 1.15)

2.1 × 10⁻¹⁰

0.009

NDA

−0.14 (−0.35, 0.08)

2.1 × 10⁻⁰¹

−0.34 (−0.51, −0.16)

1.9 × 10⁻⁰⁴

−0.53 (−0.82, −0.23)

5.4 × 10⁻⁰⁴

0.03

G/G (2090)

G/A (3142)

A/A (1066)

rs12199382

Imputed

6

24 kb 5′ of PRL

PD

0.21 (0.07, 0.36)

4.5 × 10⁻⁰³

0.51 (0.39, 0.63)

1.8 × 10⁻¹⁶

0.62 (0.41, 0.82)

2.8 × 10⁻⁰⁹

0.0006

DA

0.37 (0.17, 0.56)

2.5 × 10⁻⁰⁴

0.65 (0.49, 0.81)

1.7 × 10⁻¹⁵

0.76 (0.49, 1.03)

3.5 × 10⁻⁰⁸

0.02

NDA

−0.13 (−0.35, 0.08)

2.2 × 10⁻⁰¹

−0.35 (−0.53, −0.17)

1.1 × 10⁻⁰⁴

−0.49 (−0.79, −0.2)

1.1 × 10⁻⁰³

0.02

G/G (2629)

G/A (2873)

A/A (796)

rs9542456

Genotyped

13

505 kb 3′ of ATXN8OS

PD

0.59 (0.46, 0.73)

4.7 × 10⁻¹⁸

0.33 (0.2, 0.45)

4.1 × 10⁻⁰⁷

0.22 (−0.01, 0.45)

5.9 × 10⁻⁰²

0.0009

DA

0.75 (0.57, 0.93)

2.0 × 10⁻¹⁶

0.45 (0.28, 0.61)

1.8 × 10⁻⁰⁷

0.44 (0.14, 0.75)

4.7 × 10⁻⁰³

0.02

NDA

−0.43 (−0.63, −0.24)

1.6 × 10⁻⁰⁵

−0.27 (−0.45, −0.08)

4.7 × 10⁻⁰³

0.02 (−0.32, 0.36)

9.2 × 10⁻⁰¹

0.02

T/T (2241)

T/G (3092)

G/G (965)

rs12524161

Imputed

6

46 kb 5′ of PRL

PD

0.26 (0.12, 0.41)

2.8 × 10⁻⁰⁴

0.47 (0.35, 0.6)

3.9 × 10⁻¹⁴

0.68 (0.47, 0.89)

4.6 × 10⁻¹⁰

0.001

DA

0.42 (0.23, 0.61)

1.2 × 10⁻⁰⁵

0.6 (0.44, 0.76)

4.8 × 10⁻¹³

0.86 (0.58, 1.14)

2.6 × 10⁻⁰⁹

0.01

NDA

−0.14 (−0.35, 0.06)

1.7 × 10⁻⁰¹

−0.34 (−0.51, −0.16)

2.3 × 10⁻⁰⁴

−0.57 (−0.88, −0.26)

3.3 × 10⁻⁰⁴

0.02

C/C (5358)

C/T (899)

T/T (41)

rs17861099

Imputed

15

462 bp 5′ of CYP1A1

PD

0.48 (0.39, 0.58)

2.4 × 10⁻²¹

0.09 (−0.14, 0.32)

4.3 × 10⁻⁰¹

−0.22 (−1.8, 1.37)

7.9 × 10⁻⁰¹

0.001

DA

0.65 (0.52, 0.78)

1.1 × 10⁻²¹

0.13 (−0.17, 0.43)

3.9 × 10⁻⁰¹

0.01 (−2.09, 2.1)

9.9 × 10⁻⁰¹

0.002

NDA

−0.35 (−0.5, −0.21)

1.8 × 10⁻⁰⁶

0.02 (−0.32, 0.35)

9.2 × 10⁻⁰¹

−0.18 (−2.48, 2.13)

8.8 × 10⁻⁰¹

0.04

G/G (5337)

G/A (923)

A/A (38)

rs17861118

Imputed

15

8.3 kb 5′ of CYP1A1

PD

0.49 (0.39, 0.59)

2.6 × 10⁻²¹

0.1 (−0.12, 0.33)

3.8 × 10⁻⁰¹

−0.23 (−1.81, 1.35)

7.8 × 10⁻⁰¹

0.001

DA

0.66 (0.52, 0.79)

3.4 × 10⁻²²

0.09 (−0.21, 0.39)

5.6 × 10⁻⁰¹

−0.02 (−2.11, 2.08)

9.9 × 10⁻⁰¹

0.0006

NDA

−0.34 (−0.49, −0.19)

5.0 × 10⁻⁰⁶

−0.08 (−0.41, 0.24)

6.1 × 10⁻⁰¹

−0.18 (−2.48, 2.13)

8.8 × 10⁻⁰¹

0.08