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Table 1 Mammographic density measurements by known breast cancer risk factors, mammographic projection, and case status at time of mammography

From: A comprehensive evaluation of interaction between genetic variants and use of menopausal hormone therapy on mammographic density

Characteristic

Number (%)

PD, mean (95 % CI)a,b

Dense area, cm2, mean (95 % CI)a,b

Non-dense area, cm2, mean (95 % CI)a,b

Total

6,298 (100.0)

18.1

28.5

143.1

Age, years

    

<50

190 (3.0)

25.9 (23.8, 28.0)

32.9 (29.8, 36.1)

98.4 (92.4, 104.5)

≥50 to <60

1,948 (30.9)

21.3 (20.4, 22.2)

30.8 (29.4, 32.3)

114.9 (111.8, 118.0)

≥60 to <70

2,939 (46.7)

17.6 (16.8, 18.4)

27.0 (25.7, 28.3)

127.9 (124.7, 131.0)

≥70 to <80

1,101 (17.5)

16.7 (15.7, 17.7)

25.8 (24.2, 27.5)

131.9 (128.0, 136.0)

≥80

120 (1.9)

14.3 (12.3, 16.4)

22.1 (18.9, 25.5)

135.8 (126.9, 145.0)

BMI, kg/m2

    

<25

2,488 (39.5)

25.0 (24.0, 25.9)

30.0 (28.7, 31.4)

85.9 (83.3, 88.5)

≥25 to <30

2,244 (35.6)

17.6 (16.8, 18.4)

27.9 (26.6, 29.3)

129.0 (125.7, 132.4)

≥30 to <35

1,088 (17.3)

13.3 (12.4, 14.1)

25.5 (24.0, 27.1)

170.0 (165.5, 174.6)

≥35

478 (7.6)

10.2 (9.3, 11.2)

23.0 (21.1, 24.9)

211.3 (204.7, 217.9)

MHT use

    

never

2,885 (45.8)

16.2 (15.6, 16.9)

23.7 (22.7, 24.8)

128.3 (125.6, 131.1)

former

2,100 (33.3)

17.5 (16.8, 18.3)

26.0 (24.8, 27.3)

125.7 (122.8, 128.7)

current

1,313 (20.9)

19.9 (19.0, 20.8)

29.7 (28.2, 31.2)

121.5 (118.2, 124.9)

Parity

    

nulliparous

775 (12.3)

22.3 (21.1, 23.5)

32.7 (30.9, 34.6)

117.5 (113.6, 121.4)

1 full-term pregnancy

848 (13.5)

20.2 (19.1, 21.3)

31.0 (29.2, 32.9)

124.0 (120.0, 128.0)

2 full-term pregnancies

2,369 (37.6)

18.3 (17.5, 19.1)

27.5 (26.2, 28.9)

126.2 (123.1, 129.4)

≥3 full-term pregnancies

2,306 (36.6)

17.2 (16.5, 18.0)

25.3 (24.0, 26.6)

123.2 (120.2, 126.3)

Mammographic viewc

    

MLO

3,454 (54.8)

14.6 (14.1, 15.1)

23.3 (22.4, 24.2)

139.3 (137.1, 141.6)

CC

2,844 (45.2)

19.0 (18.5, 19.5)

29.0 (28.1, 30.0)

122.6 (120.7, 124.6)

Case status

    

non-case

4,054 (64.4)

17.0 (16.2, 17.8)

25.7 (24.5, 27.0)

128.4 (125.3, 131.6)

case

2,244 (35.6)

20.4 (19.6, 21.3)

30.0 (28.7, 31.4)

118.9 (116.0, 121.8)

  1. aBack-transformed. bAdjusted for study, reference age, use of menopausal hormone therapy (MHT), body mass index (BMI) and number of pregnancies. cIn each study mammographs were taken in either the mediolateral oblique (MLO) or craniocaudal (CC) projection. PD percent density
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Breast Cancer Research

ISSN: 1465-542X

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