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Fig. 2 | Breast Cancer Research

Fig. 2

From: Leptin produced by obese adipose stromal/stem cells enhances proliferation and metastasis of estrogen receptor positive breast cancers

Fig. 2

Leptin is essential for the adipose stromal/stem cells isolated from obese women (obASC)-driven breast cancer cell (BCC) proliferation. Adipose stromal/stem cells isolated from lean women (lnASCs) and obASCs transfected with either a control short hairpin RNA (control-shRNA) or leptin shRNA were co-cultured (CC) with BCCs. After 7 days, the green fluorescent protein-positive (GFP+) BCCs were sorted by FACS and counted. Bar represents ± standard error of the mean. *P <0.05, ***P <0.001, relative to no co-culture; ##P <0.01, ### P <0.001 between BCCs co-cultured with control shRNA lnASCs and control shRNA obASCs; ΦΦΦ P <0.001 for comparison between BCCs co-cultured with control shRNA obASCs and leptin shRNA obASCs

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Breast Cancer Research

ISSN: 1465-542X

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