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Table 1 Patient demographics and relevant clinical characteristics

From: Human breast cancer cells educate macrophages toward the M2 activation status

Factor

Entire series

CD68a

P b

CD163a

P b

HLA-Drαa

P b

 

≤369

>369

≤167.5

>167.5

≤107

>107

n = 562

n = 277

n = 274

n = 270

n = 267

n = 280

n = 275

Age, years

          

≤50

213

95

113

 

105

98

 

112

100

 

>50

349

182

161

0.093

165

169

0.602

168

175

0.378

Tumor size median

          

≤22 mm

283

144

132

 

137

129

 

140

138

 

>22 mm

278

132

142

0.348

132

138

0.545

139

137

1.000

N.A.

1

         

Nodal status

          

pN0

65

27

37

 

28

33

 

37

28

 

pN+

497

250

237

0.169

242

234

0.468

243

247

0.267

Histological type

          

Ductal

399

181

211

 

171

213

 

204

192

 

Lobular

110

66

43

 

69

33

 

47

60

 

Other

53

30

20

0.010

30

21

<0.001

29

23

0.274

Histological grade

          

Grade 1

46

33

13

 

26

16

 

20

25

 

Grade 2

264

138

119

 

153

97

 

127

132

 

Grade 3

250

106

140

0.001

91

152

<0.001

131

118

0.518

N.A.

2

         

ER status

          

Positive

405

215

181

 

214

171

 

191

207

 

Negative

157

62

93

0.003

56

96

<0.001

89

68

0.065

HER-2 status

          

Positive

170

85

83

 

72

93

 

93

77

 

Negative

392

192

191

0.920

198

174

0.040

187

198

0.183

Biological group

          

ER+, HER-2−

314

165

142

 

173

123

 

139

168

 

ER+, HER2+

91

50

39

 

41

48

 

52

39

 

ER-, HER2+

79

35

44

 

31

45

 

41

38

 

ER-, HER2−

78

27

49

0.015

25

51

<0.001

48

30

0.032

Ki67

          

≤20 %

271

149

116

 

158

96

 

124

140

 

>20 %

242

104

134

0.005

92

144

<0.001

126

116

0.252

N.A.

49

         
  1. Results are presented as number of patients. aThe cutoff values used correspond to the median values of number of positive cells in the entire series. bChi-square test. ER estrogen receptor, HER-2 human epidermal growth factor receptor 2, N.A. not available