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Fig. 4 | Breast Cancer Research

Fig. 4

From: Decoding breast cancer tissue–stroma interactions using species-specific sequencing

Fig. 4

Transcriptional consequences of xenografting MCF7 and MDA-MB-231 cells into mammary fat pads in mice. a,b Venn diagrams comparing MCF7 and MDA-MB-231 transcriptomes in vitro and in vivo. a The overlap (324 genes) between the 2142 genes that are upregulated in MCF7 tumors vs. in vitro culturing (left) and the 1456 genes that are upregulated in MDA-MB-231 tumors vs. in vitro culturing (right). b Similar analysis as in a, but for genes downregulated in MCF7 and MDA-MB-231 tumors as compared to in vitro culturing. c Principal component analysis (PCA) of untransplanted mammary gland, MCF7 tumor stroma (top to bottom: 3R, 1L, 3L) and MDA-MB-231 tumor stroma (top to bottom: 1, 32, 13, 22). d The number of genes upregulated (fold change (FC) >2) in MCF7 tumor stroma compared to MDA-MB-231 tumor stroma, as a subset of the number of genes upregulated in MCF7 or MDA-MB-231 tumor stroma compared to untransplanted mammary gland. e The number of genes downregulated (FC >2) in MCF7 tumor stroma compared to MDA-MB-231 tumor stroma, as a subset of the number of genes downregulated in MCF7 or MDA-MB-231 tumor stroma compared to untransplanted mammary gland. *p < 0.05 (Fisher’s exact test)

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