Fig. 6
From: Assessing breast cancer cell lines as tumour models by comparison of mRNA expression profiles
Genomic summary of breast cancer cells lines. Both average properties (left) and selected genetic events (right) specific to breast cancer can be used to distinguish when to use certain breast cancer cell lines. Average properties include the breast cancer subtype (luminal, basal or claudin-low), the citation frequency in the literature as an estimate of frequency of use, the average transcriptional correlation with tumours of the same subtype as determined in this study, the number of non-synonymous mutations in 1651 genes sequenced by hybrid capture, and the altered fraction of the genome. The selected genetic events include 8 possible germline mutations (ATM, BRCA1/2, BRIP1, CHEK2, NBN, PTEN and TP53), 17 possible somatic mutations (PTEN, TP53, PIK3CA, MAP3K1, MLL3, CDH1, MAP2K14, RUNX1, PIK3R1, AKT1, CBFB, CDKN1B, RB1, NF1, PTPN22, PTPRD and CCND3) and 8 possible copy number alterations (PIK3CA, ERBB2, TP53, MAP2K4, MLL3, CDKN2A, PTEN and RB1) determined to be significant in the original breast cancer study for The Cancer Genome Atlas and available on Cancer Cell Line Encyclopaedia platforms