Fig. 1
From: ALK alteration is a frequent event in aggressive breast cancers
Tissue microarray-based immunohistochemical analysis of ALK in breast cancer patients. a Normal breast tissue showing negative ALK expression. b Breast cancer TMA spot showing ALK overexpression in cytoplasmic compartment. Inset is higher magnification (40×) view showing absence of nuclear staining. c Breast cancer TMA spot showing granular dot-like ALK staining in cytoplasmic compartment. d Breast cancer TMA spot showing membranous ALK staining in cancer tissue. e Breast cancer tissue array spots showing high proliferative index of Ki-67. f Breast cancer TMA spot showing p-AKT overexpression. 20 ×/0.70 objective on an Olympus BX 51 microscope (Olympus America Inc, Center Valley, PA, USA) with the inset showing a 40× 0.85 aperture magnified view of the same. ALK anaplastic lymphoma kinase, TMA tissue microarray