Mammographic density and breast cancer in women from high risk families

Ramón y Cajal, Teresa; Chirivella, Isabel; Miranda, Josefa; Teule, Alexandre; Izquierdo, Ángel; Balmaña, Judith; Sánchez-Heras, Ana Beatriz; Llort, Gemma; Fisas, David; Lope, Virginia; Hernández-Agudo, Elena; Juan-Fita, María José; Tena, Isabel; Robles, Luis; Guillén-Ponce, Carmen; Pérez-Segura, Pedro; Luque-Molina, Mari Sol; Hernando-Polo, Susana; Salinas, Mónica; Brunet, Joan; Salas-Trejo, María Dolores; Barnadas, Agustí; Pollán, Marina

doi:10.1186/s13058-015-0604-1

Breast Cancer Research

Table 3 Association of mammographic density with subsequent breast cancer in BRCA1/2 mutation carriers

From: Mammographic density and breast cancer in women from high risk families

		All cases included				Excluding cases without a mammogram taken at least 6 months before diagnosis				Including only analog images
Mammographic density	Non-cases	BC cases	OR^a	95 % CI^a	P value^a	BC cases^a	OR^a	95 % CI^a	P value^a	Non-cases	BC cases	OR^b	95 % CI^b	P value^b
BRCA1+BRCA2
<=10 %	105	35	1.00			12	1.00			36	29	1.00
1125 %	89	47	1.51	0.74, 3.06	0.255	18	1.76	0.70, 4.41	0.228	29	41	1.74	0.72, 4.19	0.216
26−50 %	151	85	1.85	0.90, 3.82	0.095	39	2.26	0.94, 5.44	0.070	45	68	1.77	0.75, 4.15	0.191
51−75 %	72	47	3.24	1.43, 7.35	0.005	21	3.67	1.37, 9.80	0.010	15	38	4.88	1.72, 13.9	0.003
>75 %	26	34	4.34	1.71, 11.1	0.002	17	8.94	2.86, 28.0	<0.001	7	32	9.45	2.73, 32.7	<0.001
Linear trend	443	248	1.45	1.18, 1.78	<0.001	107	1.64	1.28, 2.09	<0.001	132	208	1.68	1.31, 2.15	<0.001
BRCA1
<=10 %	49	15	1.00			3	1.00			15	14	1.00
11−25 %	56	24	2.18	0.85, 5.58	0.103	8	2.71	0.63, 11.7	0.183	15	20	1.78	0.50, 6.48	0.370
26−50 %	66	36	1.90	0.78, 4.67	0.160	14	3.06	0.73, 12.9	0.127	23	30	1.15	0.39, 3.39	0.798
51−75 %	42	22	2.53	0.89, 7.18	0.082	10	4.22	0.93, 19.2	0.063	9	21	3.68	0.75, 18.1	0.109
>75 %	14	17	5.42	1.79, 16.4	0.003	9	12.0	2.20, 65.1	0.004	3	16	7.49	1.57, 35.7	0.012
Linear trend	227	114	1.37	1.06, 1.76	0.015	44	1.65	1.17, 2.32	0.004	65	101	1.51	1.08, 2.12	0.017
BRCA2
<=10 %	56	20	1.00			9	1.00			21	15	1.00
11−25 %	33	23	1.29	0.45, 3.68	0.639	10	1.70	0.47, 6.19	0.419	14	21	2.21	0.76, 6.46	0.146
26−50 %	85	49	2.03	0.65, 6.34	0.222	25	3.36	0.89, 12.7	0.074	22	38	3.85	1.06, 13.9	0.040
51−75 %	30	25	5.37	1.35, 21.4	0.017	11	7.38	1.26, 43.1	0.027	6	17	11.2	1.82, 68.9	0.009
>75 %	12	17	4.82	1.10, 21.1	0.037	8	13.4	2.33, 77.3	0.004	4	16	18.8	3.06, 114.9	0.002
Linear trend	216	134	1.60	1.13, 2.28	0.008	63	1.95	1.30, 2.91	0.001	67	107	2.11	1.40, 3.16	<0.001

^aOdds ratio (OR), 95 % CI and P values adjusted for age at mammogram, menopausal status premenopausal, natural menopause, surgical menopause), body mass index, parity (nulliparous, parous), age at first live birth, use of hormonal replacement treatment (yes, no), type of image (analog, digital) and time elapsed from mammogram to breast cancer diagnosis (cases) or end of follow up (non-cases). ^bOR, 95 % CI and P values adjusted for the above-mentioned variables except type of image

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ISSN: 1465-542X

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