Table 2 Association of mammographic density with carrier status and other characteristics in healthy female mutation carriers (controls) from BRCA1/BRCA2 families
From: Mammographic density and breast cancer in women from high risk families
Categories of mammographic density | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Variable | Number | <=10 % | 11−25 % | 26−50 % | 51−75 % | >75 % | Odds ratioa | 95 % CIa | P value |
Carrier status | |||||||||
Non-carrier | 219 | 21 % | 20 % | 33 % | 17 % | 9 % | 1.00 | ||
BRCA1 or BRCA2 | 443 | 24 % | 20 % | 34 % | 16 % | 6 % | 0.75 | 0.54, 1.04 | 0.085 |
BRCA1 | 227 | 22 % | 25 % | 29 % | 19 % | 6 % | 0.84 | 0.58, 1.23 | 0.376 |
BRCA2 | 216 | 26 % | 15 % | 39 % | 14 % | 6 % | 0.67 | 0.47, 0.96 | 0.028 |
Age at mammography, years | |||||||||
<35 | 188 | 10 % | 14 % | 36 % | 27 % | 13 % | 1.00 | ||
35−44 | 199 | 17 % | 19 % | 39 % | 17 % | 8 % | 0.94 | 0.54, 1.62 | 0.826 |
45−54 | 170 | 29 % | 25 % | 31 % | 12 % | 3 % | 0.79 | 0.33, 1.90 | 0.603 |
>=55 | 105 | 49 % | 25 % | 24 % | 3 % | 0 % | 0.57 | 0.15, 2.20 | 0.415 |
Linear trend (per year) | 0.97 | 0.95, 0.99 | <0.001 | ||||||
Body mass index | |||||||||
<25 | 396 | 10 % | 17 % | 39 % | 24 % | 10 % | 1.00 | ||
25.0−29.9 | 166 | 36 % | 26 % | 28 % | 7 % | 3 % | 0.28 | 0.19, 0.40 | <0.001 |
>=30 | 100 | 51 % | 24 % | 23 % | 2 % | 0 % | 0.16 | 0.10, 0.25 | <0.001 |
Linear trend (per unit) | 0.83 | 0.80, 0.86 | <0.001 | ||||||
Menopausal status & type of menopause | |||||||||
Premenopausal | 457 | 15 % | 17 % | 37 % | 21 % | 9 % | 1.00 | ||
Natural menopause | 142 | 41 % | 24 % | 28 % | 6 % | 1 % | 0.72 | 0.45, 1.16 | 0.179 |
Surgical menopause | 63 | 38 % | 35 % | 21 % | 6 % | 0 % | 0.56 | 0.33, 0.96 | 0.034 |
Nulliparous | |||||||||
No | 460 | 29 % | 23 % | 33 % | 13 % | 2 % | 1.00 | ||
Yes | 202 | 9 % | 14 % | 35 % | 24 % | 17 % | 1.87 | 1.28, 2.73 | 0.001 |
Age at first birth, years (only parous women) | |||||||||
>30 | 131 | 25 % | 17 % | 35 % | 17 % | 6 % | 1.00 | ||
25−29 | 170 | 25 % | 25 % | 34 % | 15 % | 1 % | 1.17 | 0.72, 1.88 | 0.526 |
20−24 | 151 | 35 % | 24 % | 30 % | 9 % | 2 % | 1.10 | 0.67, 1.82 | 0.706 |
<20 | 26 | 38 % | 23 % | 27 % | 12 % | 0 % | 0.72 | 0.31, 1.66 | 0.436 |
Linear trend (per year) | 1.00 | 0.97, 1.05 | 0.745 | ||||||
Hormonal replacement therapy | |||||||||
No | 636 | 23 % | 20 % | 34 % | 17 % | 7 % | 1.00 | ||
Yes | 26 | 23 % | 27 % | 27 % | 15 % | 8 % | 1.71 | 0.87, 3.38 | 0.120 |
Hormonal preventive therapy | |||||||||
No | 656 | 23 % | 20 % | 34 % | 17 % | 7 % | 1.00 | ||
Yes | 6 | 33 % | 17 % | 50 % | 0 % | 0 % | 0.67 | 0.25, 1.82 | 0.434 |
Oral contraception | |||||||||
No | 214 | 22 % | 18 % | 34 % | 19 % | 7 % | 1.00 | ||
Yes | 369 | 22 % | 21 % | 33 % | 17 % | 7 % | 0.93 | 0.67, 1.27 | 0.637 |
Type of image | |||||||||
Analog | 194 | 26 % | 21 % | 34 % | 13 % | 6 % | 1.00 | ||
Digital | 468 | 22 % | 20 % | 34 % | 18 % | 7 % | 1.09 | 0.79, 1.50 | 0.588 |
Number of projections | |||||||||
One or two | 53 | 15 % | 17 % | 40 % | 21 % | 8 % | 1.00 | ||
Three or Four | 609 | 24 % | 20 % | 33 % | 16 % | 7 % | 1.17 | 0.70, 1.94 | 0.544 |