Skip to main content
Fig. 4 | Breast Cancer Research

Fig. 4

From: Alternative signaling network activation through different insulin receptor family members caused by pro-mitogenic antidiabetic insulin analogues in human mammary epithelial cells

Fig. 4

Twenty mitogenic classifier genes discriminating between insulin and X10/IGF1 signaling. a Twenty genes (ten for each time point) were defined of which the gene expression was most significantly up- or downregulated in X10/IGF1 vs. insulin in the MCF7 IGF1R cell line (based on a variance test), values are presented as log2 fold changes. b Validation of 18 of these mitogenic classifier genes was successful with RT-qPCR. A comparison is given of the microarray (top panel) vs. RT-qPCR (lower panel) gene expression of the mitogenic classifiers. Expression is indicated as fold changes relative to unstimulated MCF7 IGF1R. IGF1 insulin-like growth factor 1, IGF1R IGF1receptor

Back to article page

Breast Cancer Research

ISSN: 1465-542X

Contact us