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Table 2 Single nucleotide polymorphisms associated with percent and absolute mammographic density

From: Identification of two novel mammographic density loci at 6Q25.1

     

KARMA

SASBAC

LIBRO-1

  

CHR

SNP

BP

Genes

Allelesa

MAF

beta (se)

P

MAF

beta (se)

P

MAF

beta (se)

P

P overall

P het

Percent density

6

rs9485370

149606801

TAB2

G/T

0.18

−0.05 (0.01)

2.3 × 10−5

0.17

−0.16 (0.08)

0.04

0.17

−0.16 (0.05)

3,9 × 10−4

4.8 × 10−9

0.88

10b

rs10995194

64288130

ZNF365

G/C

0.16

−0.05 (0.01)

7.1 × 10−6

0.15

−0.13 (0.08)

0.10

0.15

−0.15 (0.05)

1.9 × 10−3

2.3 × 10−8

0.62

Absolute dense

4b

rs10034692

75419787

AREG

A/G

0.32

−0.04 (0.01)

9.6 × 10−5

0.31

−0.23 (0.08)

6.1 × 10−3

0.31

−0.14 (0.04)

5.5 × 10−4

6.7 × 10−9

0.96

6

rs9485370

149606801

TAB2

G/T

0.18

−0.04 (0.01)

2.0 × 10−3

0.17

−0.22 (0.10)

0.03

0.17

−0.22 (0.05)

1.0 × 10−5

2.5 × 10−8

0.37

6

rs60705924

151955985

CCDC170-ESR1

A/G

0.31

0.04 (0.01)

1.9 × 10−4

0.31

0.33 (0.08)

3.0 × 10−5

0.31

0.09 (0.04)

0.03

2.2 × 10−8

0.13

10b

rs10995194

664288130

ZNF365

G/C

0.16

−0.07 (0.01)

1.1 × 10−6

0.15

−0.21 (0.10)

0.05

0.15

−0.15 (0.05)

5.1 × 10−3

8.7 × 10−9

0.55

  1. Genes refer to genes and nearby genes
  2. MD mammographic density, CHR chromosome, SNP single nucleotide polymorphism, BP base pair position (NCBI Build 37), MAF minor allele frequencies; P overall = P value meta-analysis; P het = P value chi-square test for heterogeneity
  3. aMajor allele (reference allele)/minor allele (effect allele)
  4. bPreviously identified in the Marker of Density (MODE) consortium: R2 rs10995194 and MODE SNP rs10995190 = 1 (1000 Genomes Project, Pilot 1 (CEU))
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Breast Cancer Research

ISSN: 1465-542X

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