Fig. 1

Regional plots of SNPs associated with percent and absolute mammographic density. a = regional association plot rs9485370 for percent density; (b) = regional association plot rs9485370 for absolute dense tissue; (c) = regional association plot rs60705924 for absolute dense tissue. Plot shows –log10 P values (y-axis) by chromosomal position (x-axis). Top genotyped SNPs (rs9485370 and rs60705924) are shown in purple. Squares denote genotyped SNPs; circles denote imputed SNPs. Colors indicate the extent of linkage disequilibrium with rs9485370 and rs60705924. Genetic recombination rates are estimated using 1000 Genomes EUR sample and are shown with the light blue line. Physical positions are based on NCBI build37 of the human genome. Note: rs9485370 falls within transcript ENST00000536230 of TAB2, which spans chr6:149539777–149731075. The plot was generated using LocusZoom software. SNP single nucleotide polymorphism