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Fig. 3 | Breast Cancer Research

Fig. 3

From: Appraisal of the technologies and review of the genomic landscape of ductal carcinoma in situ of the breast

Fig. 3

Tumour with synchronous ductal carcinoma in situ (DCIS) and invasive carcinoma showing heterogeneity of HER2 amplification and expression. (a) HER2 immunohistochemistry (IHC) showing strong circumferential membrane staining (positive for HER2) in an area of DCIS, with negative staining in adjacent DCIS and invasive carcinoma (100×). (b) HER2 silver enhanced in situ hybridisation (SISH) of same region as (a) showing DCIS with HER2 amplification and adjacent DCIS without HER2 amplification (200×). (c) Invasive carcinoma with areas showing strong circumferential membrane staining for HER2 IHC (positive for HER2) and areas negative for HER2 (100×). (d) HER2 SISH of same region as (c) showing invasive carcinoma with areas with and without HER2 amplification (200×)

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Breast Cancer Research

ISSN: 1465-542X

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