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Fig. 3 | Breast Cancer Research

Fig. 3

From: Integration of microRNA signatures of distinct mammary epithelial cell types with their gene expression and epigenetic portraits

Fig. 3

The human MaSC/basal population is enriched for primate-specific miRNAs. Primate-specific miRNAs are expressed at higher levels in the human MaSC/basal subset (MS) relative to luminal and stromal cells. a The primate-specific chromosome-19 miRNA cluster (C19MC) is located at 19q13.4, flanked by the DPRX and NLRP2 genes. C19MC is ~150 kb in length and codes for 50 known miRNAs. b Bar plots show normalized average Ct values for 15 primate-specific miRNAs that are differentially expressed between the MaSC/basal (MS), mature luminal (ML), luminal progenitor (LP) and stromal (str) cell subsets. Quantitative PCR data was normalized against the U6 small RNA (n = 3 independent biological samples; error bars represent SEM). c The table shows known or putative mRNA targets of DE primate-specific miRNAs in human breast epithelium

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