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Fig. 1 | Breast Cancer Research

Fig. 1

From: Integration of microRNA signatures of distinct mammary epithelial cell types with their gene expression and epigenetic portraits

Fig. 1

Global miRNA expression in sorted populations from mouse and human mammary glands. Mouse and human epithelial subsets are marked by unique miRNA expression signatures. a Multi-dimensional scaling plots indicate clear separation of the mammary stem cell (MaSC)/basal-enriched, luminal progenitor (LP), mature luminal (ML) and stromal subsets in both mouse (left panel) and human (right panel). Distances on the plot represent the log2 fold change for a typical miRNA between the samples. Stromal cells are well separated from the epithelial subsets, with a typical expression change of around 5 logs or 32-fold. The MaSC/basal subset is well separated from the luminal subsets with a typical expression change of around 4 logs or 16-fold. b Combined heat map shows hierarchical clustering of all conserved miRNAs in mouse and human epithelial subsets including stromal subsets (red = high expression; blue = low expression)

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