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Fig. 2 | Breast Cancer Research

Fig. 2

From: Serial expression analysis of breast tumors during neoadjuvant chemotherapy reveals changes in cell cycle and immune pathways associated with recurrence and response

Fig. 2

Association between gene expression and response to chemotherapy as defined by residual cancer burden (RCB). a Scatterplot showing the expression of a representative cell proliferation gene, CDKN2B, at baseline (T1) and 24–96 hours after initiation of chemotherapy (T2) with the color of the points indicating response [red = RCB 0/I (responders); blue = RCB II/III (nonresponders)]. The diagonal line represents no change in gene expression levels (T1 = T2). The length of the vertical lines between points and the diagonal line represents the magnitude of expression change from T1 to T2. bd Box plots show expression of CDKN2B in RCB 0/I and RCB II/III at T1 (b), at T2 (c) and the change in gene expression between two time points (T2 − T1) (d)

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