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Table 3 Multivariatea-adjusted geometric mean and 95% confidence interval (CI) for percent dense breast volume by quartiles of androgens and SHBG at pre-b and postmenarchealb periods

From: Adolescent endogenous sex hormones and breast density in early adulthood

Quartiles Premenarche Postmenarche All periods
  Mean (95 % CI) Mean (95 % CI) Mean (95 % CI)
Androstenedione N = 153   N = 154   N = 174
 Q1 20.2 (17.2-23.7) 17.9 (14.6-22.1) 19.2 (16.5-22.3)
 Q2 18.8 (14.9-23.8) 19.4 (14.8-25.5) 19.2 (14.7-24.9)
 Q3 18.1 (13.5-24.1) 18.0 (14.4-22.3) 18.0 (15.2-21.3)
 Q4 17.4 (11.0-27.6) 17.9 (13.7-23.5) 18.6 (14.1-24.6)
P-trendc 0.30   0.88   0.69  
DHEAS N = 153   N = 156   N = 176
 Q1 16.7 (12.7-22.0) 19.9 (13.6-29.1) 18.7 (14.2-24.5)
 Q2 19.6 (14.2-26.9) 16.3 (12.1-22.1) 17.5 (14.6-20.9)
 Q3 16.6 (13.2-20.9) 17.0 (14.5-20.0) 17.5 (15.1-20.3)
 Q4 22.1 (17.3-28.0) 20.3 (17.9-22.9) 21.5 (18.2-15.4)
P-trendc <0.001   0.84   0.10  
Testosterone N = 150   N = 156   N = 175
 Q1 17.6 (14.8-20.9) 16.7 (14.1-19.7) 18.5 (15.2-22.6)
 Q2 20.5 (18.4-22.7) 18.6 (14.8-23.3) 19.2 (16.3-22.7)
 Q3 18.0 (12.0-26.9) 18.2 (12.5-26.4) 18.7 (14.7-23.8)
 Q4 17.7 (11.5-27.2) 19.8 (17.4-22.6) 18.2 (14.1-23.6)
P-trendc 0.90   0.16   0.87  
SHBG N = 153   N = 156   N = 176
 Q1 14.4 (10.2-20.4) 15.7 (11.0-22.6) 15.5 (12.8-18.7)
 Q2 18.7 (15.3-22.8) 17.1 (12.9-22.7) 17.5 (13.3-23.1)
 Q3 18.3 (14.6-22.9) 25.0 (18.0-24.6) 22.1 (20.2-24.2)
 Q4 24.3 (19.6-30.1) 16.7 (14.8-18.8) 20.5 (15.6-26.9)
P-trendc 0.03   0.42   0.05  
  1. Abbreviations: CI confidence interval, DHEAS, dehydroepiandrosterone sulfate; SHBG, sex hormone-binding globulin
  2. aGeometric means and 95 % CI are estimated from linear mixed-effects models including clinic as a random effect and adjusted for treatment group (diet intervention group, usual-care control group, BMI (kg/m2, continuous), parity (0 and >0), duration of hormone use (yrs, continuous), race (white and nonwhite), and education (bachelor's degree, graduate school and other) as fixed effects
  3. bThe androgens and SHBG levels were standardized by adjusting for age at visit, BMI z-score at visit, and visit number in years after randomization by residual method
  4. c P-test for trend was conducted by modeling the quartile medians of standardized hormone concentrations as a continuous term in linear mixed-effects models and calculating the Wald test statistic
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