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Table 1 Comparison of the fibroglandular tissue and background parenchymal enhancement measures before and after risk-reducing salpingo-oophorectomy

From: Quantitative assessment of background parenchymal enhancement in breast MRI predicts response to risk-reducing salpingo-oophorectomy: preliminary evaluation in a cohort of BRCA1/2 mutation carriers

  |FGT| [cm3] FGT % [ %] |BPE| SUB 1 [cm3] BPE % SUB 1 [ %] |BPE| SUB 3 [cm3] BPE % SUB 3 [ %]
44 women who did not develop breast cancer post-RRSO Pre-RRSO 83.2 ± 63.8 11.3 ± 8.1 28.2 ± 44.2 3.8 ± 4.5 43.0 ± 49.7 6.0 ± 5.9
Post-RRSO 60.4 ± 50.1 10.3 ± 7.5 12.2 ± 11.8 2.3 ± 1.8 21.0 ± 15.2 3.9 ± 2.5
P value 0.005 0.23 0.027 0.045 0.005 0.015
FDR-corrected P value 0.03 0.34 0.06 0.078 0.03 0.046
6 women who developed breast cancer post-RRSO Pre-RRSO 65.1 ± 60.2 11.6 ± 3.8 26.7 ± 12.6 7.3 ± 4.6 40.0 ± 31.3 8.2 ± 3.8
Post-RRSO 72.9 ± 38.2 11.2 ± 7.6 20.5 ± 19.2 3.3 ± 2.3 33.6 ± 20.1 5.4 ± 3.2
P value 0.78 0.83 0.48 0.035 0.68 0.0096
FDR-corrected P value 0.83 0.83 0.64 0.070 0.82 0.038
ANOVA P-value 0.83 0.24 0.058 0.0057 0.021 0.023
FDR-corrected ANOVA P-value 0.83 0.29 0.087 0.034 0.046 0.046
AUC 0.66 0.57 0.48 0.78 0.66 0.65
  1. Data are presented as mean ± SD, where background parenchymal enhancement (BPE) is estimated using the representative R %cutoff of 30 % for subtraction images 1 and 3 (i.e., post-contrast minus pre-contrast; SUB 1 and SUB 3, respectively). P values were derived by paired Student’s t test comparing pre-RRSO and post-RRSO measures for each group. In analysis of variance, the P values represent our jointly contrasting the groups developing vs. not developing cancer and pre-RRSO vs. post-RRSO status as the two independent variables. False discovery rate (FDR)-corrected P values are also provided as a means to adjust for multiple comparisons. AUC refers to the area under the receiver operating characteristic curve for the logistic regression models to predict women who developed breast cancer after RRSO, based on the relative differences (i.e., [post-RRSO − pre-RRSO]/pre-RRSO) in each measure. Abbreviation: RRSO, Risk-reducing salpingo-oophorectomy