Quantitative assessment of background parenchymal enhancement in breast MRI predicts response to risk-reducing salpingo-oophorectomy: preliminary evaluation in a cohort of BRCA1/2 mutation carriers

Table 1 Comparison of the fibroglandular tissue and background parenchymal enhancement measures before and after risk-reducing salpingo-oophorectomy

		\|FGT\| [cm³]	FGT % [ %]	\|BPE\| SUB 1 [cm³]	BPE % SUB 1 [ %]	\|BPE\| SUB 3 [cm³]	BPE % SUB 3 [ %]
44 women who did not develop breast cancer post-RRSO	Pre-RRSO	83.2 ± 63.8	11.3 ± 8.1	28.2 ± 44.2	3.8 ± 4.5	43.0 ± 49.7	6.0 ± 5.9
	Post-RRSO	60.4 ± 50.1	10.3 ± 7.5	12.2 ± 11.8	2.3 ± 1.8	21.0 ± 15.2	3.9 ± 2.5
	P value	0.005	0.23	0.027	0.045	0.005	0.015
	FDR-corrected P value	0.03	0.34	0.06	0.078	0.03	0.046
6 women who developed breast cancer post-RRSO	Pre-RRSO	65.1 ± 60.2	11.6 ± 3.8	26.7 ± 12.6	7.3 ± 4.6	40.0 ± 31.3	8.2 ± 3.8
	Post-RRSO	72.9 ± 38.2	11.2 ± 7.6	20.5 ± 19.2	3.3 ± 2.3	33.6 ± 20.1	5.4 ± 3.2
	P value	0.78	0.83	0.48	0.035	0.68	0.0096
	FDR-corrected P value	0.83	0.83	0.64	0.070	0.82	0.038
ANOVA P-value		0.83	0.24	0.058	0.0057	0.021	0.023
FDR-corrected ANOVA P-value		0.83	0.29	0.087	0.034	0.046	0.046
AUC		0.66	0.57	0.48	0.78	0.66	0.65

Data are presented as mean ± SD, where background parenchymal enhancement (BPE) is estimated using the representative R %_cutoff of 30 % for subtraction images 1 and 3 (i.e., post-contrast minus pre-contrast; SUB 1 and SUB 3, respectively). P values were derived by paired Student’s t test comparing pre-RRSO and post-RRSO measures for each group. In analysis of variance, the P values represent our jointly contrasting the groups developing vs. not developing cancer and pre-RRSO vs. post-RRSO status as the two independent variables. False discovery rate (FDR)-corrected P values are also provided as a means to adjust for multiple comparisons. AUC refers to the area under the receiver operating characteristic curve for the logistic regression models to predict women who developed breast cancer after RRSO, based on the relative differences (i.e., [post-RRSO − pre-RRSO]/pre-RRSO) in each measure. Abbreviation: RRSO, Risk-reducing salpingo-oophorectomy

ISSN: 1465-542X