Magnetic hyperthermia treatment with magnetic nanoparticles (MNP) led to a significant reduction in tumor volume compared to untreated animals. Tumor volume was calculated relative to the tumor volume at day 0 (Vt0) in percent. a Tumor volume development after magnetic hyperthermia (60 minutes at H = 15.4 kA/m, f = 435 kHz) with the different MNP formulations compared to the untreated control (ddH
0, no magnetic hyperthermia). b Effect of intratumoral presence of MNP without hyperthermia treatment on tumor volume as well as the ddH
0 control (*p ≤0.05, Mann-Whitney U test, treated vs untreated). Means and SD of n ≥6 animals/group.