Individual temperature dosages over tumor areas. a By using tumor surface temperature during hyperthermia treatment, median temperature dosages were calculated as cumulative equivalent minutes (CEM43T90) and displayed as box plots. b Example of a treatment sequence within the alternating magnetic field (AMF), the corresponding temperature distribution over the tumor surface and the effect on tumor volume. c Intratumoral distribution of magnetic nanoparticles (MNP) (MF66-N6LDOX) was determined using micro computed tomography 24 h prior to the first hyperthermia treatment. N6L Nucant multivalent pseudopeptide, DOX doxorubicin.