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Figure 6 | Breast Cancer Research

Figure 6

From: Efficient treatment of breast cancer xenografts with multifunctionalized iron oxide nanoparticles combining magnetic hyperthermia and anti-cancer drug delivery

Figure 6

Color-coded map of multiparametric cytotoxicity evaluation in three breast cell lines (two with distinct cancer phenotypes (MCF7 and MDA-MB-231) and one normal-like (MCF10A)) exposed to magnetic nanoparticles (MNP) for 24 h and 72 h. Controls are free Nucant multivalent pseudopeptide (N6L), free doxorubicin (DOX) and untreated cells. Each segment represents the analysis of n = 3 experiments with triplicate wells for each parameter: cell count reduction, lysosomal mass and cell permeability as indicated. Colorimetric gradient ranges from: dark green = <15% of maximum value measured; bright green = 30%; yellow = 50%; bright orange = 60%; dark orange = 75%; red = >75%. Color-coded map values are normalized using the percentage of the negative controls. N/C negative control, P/C positive control.

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