Table 1 Univariate and multivariate analysis of elafin-positive cells in breast cancer patients
A. Univariate analysis, breast cancer (n = 793) | ||||
|---|---|---|---|---|
Factors | Elafin negative (n = 311) | Elafin positive (n = 482) | p-value | |
Age of diagnosis, year | Â | Â | 0.02 | |
  Mean | 55.5 | 53.5 |  | |
  Median (range) | 55 (26–86) | 52 (25–87) |  | |
Stage | Â | Â | <0.0001 | |
  I | 120 (38.7) | 115 (24.0) |  | |
  IIA | 128 (41.3) | 241 (50.2) |  | |
  IIB | 62 (20.0) | 124 (25.8) |  | |
  Unknown | 1 | 2 |  | |
ER | Â | Â | <0.0001 | |
  Positive | 266 (85.5) | 280 (58.3) |  | |
  Negative | 45 (14.5) | 200 (41.7) |  | |
  Unknown | 0 | 2 |  | |
PR | Â | Â | <0.0001 | |
  Positive | 218 (70.1) | 236 (49.2) |  | |
  Negative | 93 (29.9) | 244 (50.8) |  | |
  Unknown | 0 | 2 |  | |
HER-2 | Â | Â | 0.013 | |
  Positive | 42 (13.5) | 98 (20.4) |  | |
  Negative | 269 (86.5) | 383 (79.6) |  | |
  Unknown | 0 | 1 |  | |
Grade | Â | Â | <0.0001 | |
  I | 41 (14.2) | 31 (6.8) |  | |
  II | 186 (64.6) | 197 (43.5) |  | |
  III | 61 (21.2) | 225 (49.7) |  | |
  Unknown | 23 | 29 |  | |
Tumor subtype | Â | Â | <0.0001 | |
  Luminal A | 185 (61.9) | 158 (33.1) |  | |
  Luminal B | 45 (15.1) | 94 (19.8) |  | |
  Her2 positive | 42 (14.0) | 98 (20.7) |  | |
  Triple negative | 27 (9.0) | 125 (26.4) |  | |
  Unknown | 12 | 7 |  | |
Recurrence | Â | Â | <0.0001 | |
  No | 250 (80.9) | 298 (62.3) |  | |
  Yes | 59 (19.1) | 180 (37.7) |  | |
  Unknown | 2 | 4 |  | |
B. Multivariate Cox proportional hazards analysis of clinicopathologic variables’ influence on breast cancer RFS in whole cohort (n = 793) | ||||
Factor | HR | Se | P | 95% CI |
Stage | Â | Â | Â | Â |
  I | referent |  |  |  |
  IIA | 1.67 | 0.31 | 0.005 | 1.17-2.39 |
  IIB | 2.41 | 0.47 | <0.0001 | 1.65-3.52 |
Age | 0.98 | 0.01 | <0.0001 | 0.97-0.99 |
Elafin Positive | 1.94 | 0.3 | <0.0001 | 1.44-2.62 |