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Table 2 Previously reported associations replicated in the meta-analysis

From: Common germline polymorphisms associated with breast cancer-specific survival

      

All cases

ER-negative cases

ER-positive cases

SNP

Gene

Published

Model

Effect allele

Effect allele freq

HR (90% CI)

One-sided

HR (90% CI)

One-sided

HR (90% CI)

One-sided

P value

P value

P value

rs2981582

FGFR2

Bayraktar et al. [34]

Dominance

G

0.57

1.09 (1.04-1.14)

0.00085

1.08 (1.00-1.16)

0.052

1.04 (0.98-1.10)

0.15

rs1800566

NQO1

Fagerholm et al. [14]

Dominance

A

0.19

1.10 (1.03-1.17)

0.0046

1.14 (1.03-1.25)

0.015

1.04 (0.95-1.13)

0.23

rs9934948

LOC100506172

Shu et al. [6] (GWAS)

Co-dominance

T

0.15

0.92 (0.86-0.98)

0.011

0.90 (0.79-1.01)

0.059

0.95 (0.86-1.04)

0.18

rs1800470

TGF

Shu et al. [6]

Co-dominance

A

0.61

0.95 (0.91-0.99)

0.030

0.96 (0.88-1.04)

0.20

0.95 (0.88-1.02)

0.12

rs3775775

SULT1E1

Choi et al. [47]

Dominance

G

0.09

1.08 (1.00-1.16)

0.046

1.17 (1.03-1.31)

0.02

1.06 (0.95-1.17)

0.18

rs700519

CYP19A1

Long et al. [55]

Dominance

A

0.03

1.10 (0.98-1.22)

0.093

1.03 (0.83-1.23)

0.40

1.30 (1.10-1.50)

0.0050

rs731236

VDR

Perna et al. [66]

Co-dominance

G

0.39

1.04 (1.00-1.08)

0.056

1.03 (0.95-1.11)

0.28

1.09 (1.02-1.16)

0.017

rs12900137

CYP19A1

Long et al. [55]

Dominance

C

0.05

1.01 (0.91-1.11)

0.47

0.94 (0.78-1.10)

0.70

1.18 (1.02-1.34)

0.032

rs10477313

PPP2R2B

Jamshidi et al. [35]

Dominance

T

0.12

0.94 (0.87- 1.01)

0.08

0.92 (0.79-1.05)

0.15

0.88 (0.77-0.99)

0.035

rs2333227

MPO

Ambrosone et al. [45]

Dominance

T

0.21

1.03 (0.97-1.09)

0.20

0.95 (0.87-1.03)

0.78

1.09 (1.01-1.17)

0.036

rs1902586

CYP19A1

Long et al. [55]

Dominance

A

0.05

1.01 (0.91-1.11)

0.44

0.99 (0.83-1.15)

0.54

1.16 (1.01-1.31)

0.041

rs28566535

CYP19A1

Long et al. [55]

Dominance

C

0.05

1.00 (0.90-1.10)

0.51

0.97 (0.81-1.13)

0.60

1.15 (1.00-1.30)

0.046

  1. Hazard ratios are for breast cancer-specific survival using a Cox proportional hazards model corrected for principal components; hazard ratios, confidence intervals and P values are from a co-dominant model; P values refer to a one-sided test of association in the direction indicated in bold in the 90% CI of the HR; P values in bold indicate results that are nominally significant (P <0.05). HR, hazard ratio; CI, confidence interval; GWAS, genome-wide association study.
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Breast Cancer Research

ISSN: 1465-542X

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