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Table 2 Previously reported associations replicated in the meta-analysis

From: Common germline polymorphisms associated with breast cancer-specific survival

       All cases ER-negative cases ER-positive cases
SNP Gene Published Model Effect allele Effect allele freq HR (90% CI) One-sided HR (90% CI) One-sided HR (90% CI) One-sided
P value P value P value
rs2981582 FGFR2 Bayraktar et al. [34] Dominance G 0.57 1.09 (1.04-1.14) 0.00085 1.08 (1.00-1.16) 0.052 1.04 (0.98-1.10) 0.15
rs1800566 NQO1 Fagerholm et al. [14] Dominance A 0.19 1.10 (1.03-1.17) 0.0046 1.14 (1.03-1.25) 0.015 1.04 (0.95-1.13) 0.23
rs9934948 LOC100506172 Shu et al. [6] (GWAS) Co-dominance T 0.15 0.92 (0.86-0.98) 0.011 0.90 (0.79-1.01) 0.059 0.95 (0.86-1.04) 0.18
rs1800470 TGF Shu et al. [6] Co-dominance A 0.61 0.95 (0.91-0.99) 0.030 0.96 (0.88-1.04) 0.20 0.95 (0.88-1.02) 0.12
rs3775775 SULT1E1 Choi et al. [47] Dominance G 0.09 1.08 (1.00-1.16) 0.046 1.17 (1.03-1.31) 0.02 1.06 (0.95-1.17) 0.18
rs700519 CYP19A1 Long et al. [55] Dominance A 0.03 1.10 (0.98-1.22) 0.093 1.03 (0.83-1.23) 0.40 1.30 (1.10-1.50) 0.0050
rs731236 VDR Perna et al. [66] Co-dominance G 0.39 1.04 (1.00-1.08) 0.056 1.03 (0.95-1.11) 0.28 1.09 (1.02-1.16) 0.017
rs12900137 CYP19A1 Long et al. [55] Dominance C 0.05 1.01 (0.91-1.11) 0.47 0.94 (0.78-1.10) 0.70 1.18 (1.02-1.34) 0.032
rs10477313 PPP2R2B Jamshidi et al. [35] Dominance T 0.12 0.94 (0.87- 1.01) 0.08 0.92 (0.79-1.05) 0.15 0.88 (0.77-0.99) 0.035
rs2333227 MPO Ambrosone et al. [45] Dominance T 0.21 1.03 (0.97-1.09) 0.20 0.95 (0.87-1.03) 0.78 1.09 (1.01-1.17) 0.036
rs1902586 CYP19A1 Long et al. [55] Dominance A 0.05 1.01 (0.91-1.11) 0.44 0.99 (0.83-1.15) 0.54 1.16 (1.01-1.31) 0.041
rs28566535 CYP19A1 Long et al. [55] Dominance C 0.05 1.00 (0.90-1.10) 0.51 0.97 (0.81-1.13) 0.60 1.15 (1.00-1.30) 0.046
  1. Hazard ratios are for breast cancer-specific survival using a Cox proportional hazards model corrected for principal components; hazard ratios, confidence intervals and P values are from a co-dominant model; P values refer to a one-sided test of association in the direction indicated in bold in the 90% CI of the HR; P values in bold indicate results that are nominally significant (P <0.05). HR, hazard ratio; CI, confidence interval; GWAS, genome-wide association study.
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