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Table 1 Previously identified breast cancer survival genes in cancer-related pathways

From: Common germline polymorphisms associated with breast cancer-specific survival

Pathway

Nearest gene

References

DNA repair

XRCC1, XRCC2, XRCC3, RAD51B, LIG4, ERCC2

[6,28-32]

Cell cycle control

CCND1, CCND3, PRKAG2, TP53, SIPA1, FGFR2, PPP2R2B

[28,33-38]

Matrix metalloproteinases

MMP7, MMP8, MMP2, SERPINE1, TIMP-3

[23,40-44]

Immune and drug response, metabolism

Il-10, IL-6, IL-21, MPO, GSTP1, COMT, CYP19A1, CYP1A1, SULT1E1, NEF2L2, TLR4, SLC28A3, CD24, CD44, NQO1

[14,22,24,45-57]

Tumour progression

NOS3, VEGF, NME1, SELE, GNAS1, ZFP36, TGF

[58-64]

Vitamin D receptors

RXRA, VDR

[65,66]

Miscellaneous

TOX3, MTHFR, COX11, OCA2, PLAUR.

[4,7,34,65,67]

  1. NB: the genes mentioned here are the candidate genes listed in the previous publications or are the nearest gene to the single nucleotide polymorphism (SNP) and are not necessarily the genes on which the SNPs have a functional effect.