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Table 1 Previously identified breast cancer survival genes in cancer-related pathways

From: Common germline polymorphisms associated with breast cancer-specific survival

Pathway Nearest gene References
DNA repair XRCC1, XRCC2, XRCC3, RAD51B, LIG4, ERCC2 [6,28-32]
Cell cycle control CCND1, CCND3, PRKAG2, TP53, SIPA1, FGFR2, PPP2R2B [28,33-38]
Matrix metalloproteinases MMP7, MMP8, MMP2, SERPINE1, TIMP-3 [23,40-44]
Immune and drug response, metabolism Il-10, IL-6, IL-21, MPO, GSTP1, COMT, CYP19A1, CYP1A1, SULT1E1, NEF2L2, TLR4, SLC28A3, CD24, CD44, NQO1 [14,22,24,45-57]
Tumour progression NOS3, VEGF, NME1, SELE, GNAS1, ZFP36, TGF [58-64]
Vitamin D receptors RXRA, VDR [65,66]
Miscellaneous TOX3, MTHFR, COX11, OCA2, PLAUR. [4,7,34,65,67]
  1. NB: the genes mentioned here are the candidate genes listed in the previous publications or are the nearest gene to the single nucleotide polymorphism (SNP) and are not necessarily the genes on which the SNPs have a functional effect.
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