Figure 4

C2/C3 immune response dissection. (A) Ward’s hierarchical clustering and heatmap showing the segregation of C2 (red) and C3 (green) patients as a function of the seven Rody’s metagenes (B lymphocytes (IgG); macrophages and monocyte/myeloid lineage cells (HCK); professional antigen-presenting cells (MHC-II); T-cell (LCK); cell types for presentation of intracellular antigens (MHC-I); interferon signal transduction (STAT1); interferon response (interferon)) and M2/M1 gene-expression signature (GES) (continuous colour scale, from minimum (8.05, 6.90, 5.06, 7.84, 7.43, 9.68, 11.19 and −1.36 for HCK, LCK, IgG, STAT1, Interferon, MHC-II, MHC-I and M2/M1 GES, respectively; deep sky blue) to maximum (11.46, 12.24, 12.93, 13.21, 12.55, 13.75, 14.69 and −0.68 for HCK, LCK, IgG, STAT1, Interferon, MHC-II, MHC-I and M2/M1 GES, respectively; red). (B) Kaplan-Meier curves for event-free survival (EFS) analysis of breast cancer patients with high immune response (HIR) and low immune response (LIR).