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Table 5 Significant correlations between TFPI single nucleotide polymorphisms (SNPs) and total TFPI protein levels in plasma

From: Tumor expression, plasma levels and genetic polymorphisms of the coagulation inhibitor TFPI are associated with clinicopathological parameters and survival in breast cancer, in contrast to the coagulation initiator TF

Protein

SNP

Region

Alleles a

Minor allele frequency

Beta

r

P

False discovery rate

Total TFPI

rs8176541b

Intronic

G:A

0.283

15.64

0.571

7.69 × 10−14

1.08 × 10−12

Total TFPI

rs3213739b

Intronic

G:T

0.417

11.35

0.488

5.38 × 10−10

3.77 × 10−9

Total TFPI

rs8176479b

Intronic

C:A

0.238

12.22

0.480

1.20 × 10−9

5.62 × 10−9

Total TFPI

rs2192824b

Intronic

C:T

0.490

−9.88

−0.404

3.81 × 10−7

1.07 × 106

Total TFPI

rs2192825b

Intronic

T:C

0.466

−7.55

−0.301

2.40 × 10−4

5.30 × 10−4

Total TFPI

rs16829088b

Intronic

G:A

0.250

11.23

0.424

1.00 × 10−7

3.51 × 10−7

Total TFPI

rs7594359b

Intronic

C:T

0.483

−6.90

−0.275

6.90 × 10−4

0.001

Total TFPI

rs10153820b

Near 5UTR

G:A

0.125

−7.79

−0.215

0.009

0.016

  1. aMajor:minor. bSNPs representing a haplotype effect for total tissue factor pathway inhibitor (TFPI). Alleles for the positive DNA strand (UCSC annotated) are shown.