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Figure 5 | Breast Cancer Research

Figure 5

From: Lectin RCA-I specifically binds to metastasis-associated cell surface glycans in triple-negative breast cancer

Figure 5

Inhibition of TNBC cell motilities by RCA-I. (a) Transwell assays were performed in the presence of different concentrations of RCA-I using three TNBC cell lines that differed in metastatic capacity. There is a clear dose-dependent inhibition of invasion by RCA-I with each cell line. (b to m) Cell motility characteristics determined with RTCA. In each figure, the concentration of RCA-I employed is indicated in the inset to Figure 4b. For the invasion, migration and adhesion assays, the cell index (CI) is linearly proportional to the number of invaded, migrated and adhered cells, respectively. (b to e) Invasion assays, (f to i) migration assays, and (j to m) adhesion assays. RCA-I, Ricinus communis agglutinin I; RTCA, real-time cell analyzer; TNBC, triple-negative breast cancer.

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Breast Cancer Research

ISSN: 1465-542X

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