Figure 7

The MaSC gene signature is enriched in normal-like not claudin-low tumours. The DART activation score of the MaSC gene signature across breast carcinomas of METABRIC breast cancer cohort. The classification of this cohort into molecularly defined breast cancer subtypes was based on their previously published PAM50 centroid correlation (upper panel) (basal-like in red, HER2 in pink, luminal A in dark blue, luminal B in light blue, and normal-like in green) and across the 10 previously defined IntClust subgroups (lower panel). Number of tumours is shown underneath each subtype. The DART activation score of the MaSC gene signature is shown on the y-axis in both plots. DART, Denoising Algorithm based on Relevance network Topology; HER2, human epidermal growth factor receptor 2; MaSC, mammary stem cell.