Figure 6From: Genetic depletion and pharmacological targeting of αv integrin in breast cancer cells impairs metastasis in zebrafish and mouse xenograft models GLPG0187 inhibits progression of established bone metastasis. (A) Bioluminescent imaging at week 6 of two representative mice injected with MDA-MB-231 cells and administered with vehicle or GLPG0187 (100 mg/kg) weekly. (B) Representative radiographic images illustrating GLPG0187 (100 mg/kg) efficacy on associated osteolytic lesions in this mouse model of human breast cancer bone metastasis.Back to article page