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Table 3 Hazard ratios for invasive breast cancer for increased intake of 0.43 pg/kg body weight/day, according to quartiles of estimated dietary dioxin exposure and hormone receptor status (n = 63,830), 1993 to 2008

From: Estimated dietary dioxin exposure and breast cancer risk among women from the French E3N prospective cohort

   Dietary dioxin exposure (pg/kg body weight/day)
Populations c /0.43 <0.98 (ref) [0.98, 1.23] [1.23, 1.52] ≥1.52 P -trend
 Cases, n 3465 880 853 848 884  
 HR (95% CI)a 1.01 (0.99, 1.03) 1.00 0.97 (0.88, 1.06) 0.96 (0.88, 1.06) 1.02 (0.92, 1.11) 0.4181
 HR (95% CI)b 1.00 (0.96, 1.05) 1.00 0.94 (0.86, 1.04) 0.93 (0.83, 1.03) 0.96 (0.85, 1.09) 0.9405
ER+/PR+ d       
 Cases, n 1596 410 388 389 409  
 HR (95% CI)a 1.02 (0.98, 1.07) 1.00 0.94 (0.82, 1.08) 0.95 (0.82, 1.09) 1.00 (0.88, 1.15) 0.5328
 HR (95% CI)b 1.00 (0.93, 1.07) 1.00 0.91 (0.79, 1.06) 0.90 (0.77, 1.05) 0.94 (0.78, 1.12) 0.9678
ER+/PR- d       
 Cases, n 561 131 146 137 147  
 HR (95% CI)a 1.04 (0.96, 1.13) 1.00 1.12 (0.88, 1.41) 1.05 (0.83, 1.34) 1.14 (0.90, 1.45) 0.3565
 HR (95% CI)b 1.04 (0.93, 1.17) 1.00 1.10 (0.86, 1.41) 1.03 (0.79, 1.35) 1.14 (0.84, 1.54) 0.4571
ER-/PR- d       
 Cases, n 414 109 103 104 98  
 HR (95% CI)a 0.96 (0.87, 1.06) 1.00 0.93 (0.71, 1.22) 0.94 (0.72, 1.23) 0.89 (0.67, 1.16) 0.4221
 HR (95% CI)b 0.88 (0.77, 1.01) 1.00 0.86 (0.65, 1.13) 0.81 (0.60, 1.10) 0.72 (0.50, 1.02) 0.0629
  1. aAge-adjusted models; badjusted for age, height, body mass index, energy intake, education, physical activity, smoking status, menopausal status combined with use of menopausal hormone treatment, alcohol intake, age at menarche, use of oral contraceptives, use of progestin, age at menopause, age at first full-term pregnancy and number of live births, breastfeeding, family history of breast cancer, history of personal benign breast disease and mammography; cER-/PR+ invasive breast cancer risk was not analyzed due to small number of cases (n = 107); dn = 787 invasive breast cancer cases with missing hormone receptor status. HR, hazard ratio.