Skip to main content

Table 3 Oral contraceptive use in relation to triple-negative breast cancer a

From: A case–control analysis of oral contraceptive use and breast cancer subtypes in the African American Breast Cancer Epidemiology and Risk Consortium

 

Controls ( n )

Cases ( n )

OR

(95% CI)

Never users

4,632

213

1.00

Reference

Ever users

5,415

282

1.14

(0.93 to 1.40)

OC recency

    

  < 5 years ago

1,075

66

1.78

(1.25 to 2.53)

 5 to 9 years ago

544

33

1.37

(0.88 to 2.12)

 10 to 14 years ago

595

37

0.99

(0.63 to 1.56)

 15 to 19 years ago

757

47

1.19

(0.83 to 1.72)

 20 to 24 years ago

859

40

0.85

(0.89 to 1.24)

 25 to 29 years ago

781

40

1.26

(0.87 to 1.81)

  ≥ 30 years ago

795

30

0.91

(0.59 to 1.38)

P trend

  

0.05

OC duration

    

  < 5 years

2,315

117

1.08

(0.84 to 1.39)

 5 to 9 years

1,629

73

0.99

(0.74 to 1.34)

 10 to 14 years

1,010

51

1.26

(0.90 to 1.77)

  ≥ 15 years

458

40

1.62

(1.11 to 2.38)

P trend

  

0.05

Joint OC exposure

    

Since last use

Duration

    

< 5 years

< 5 years

329

14

1.31

(0.72 to 2.40)

 

5 to 9 years

289

21

2.70

(1.58 to 4.61)

 

≥ 10 years

457

30

1.66

(1.06 to 2.60)

5 to 9 years

< 5 years

172

5

0.89

(0.35 to 2.30)

 

5 to 9 years

140

7

1.08

(0.47 to 2.48)

 

≥ 10 years

232

19

1.79

(1.04 to 3.07)

10 to 19 years

< 5 years

466

26

1.12

(0.70 to 1.79)

 

5 to 9 years

451

21

0.87

(0.53 to 1.45)

 

≥ 10 years

435

27

1.36

(0.87 to 2.11)

≥ 20 years

< 5 years

1,344

72

1.11

(0.83 to 1.49)

 

5 to 9 years

748

22

0.67

(0.42 to 1.06)

 

≥ 10 years

340

15

1.14

(0.65 to 2.00)

  1. CI, confidence interval; OC, oral contraceptive; OR, odds ratio. aORs adjusted for age, study, time period, geographic region, education, age at menarche, parity, age at first birth, lactation, first-degree family history of breast cancer, menopausal status and age at menopause, duration of female hormone use, body mass index, alcohol consumption, and pack-years of cigarette smoking. P trend does not include never users.