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Table 2 Oral contraceptive use in relation to ER+ and ER– breast cancer a

From: A case–control analysis of oral contraceptive use and breast cancer subtypes in the African American Breast Cancer Epidemiology and Risk Consortium

  

ER+

ER–

 

Controls ( n )

Cases ( n )

OR

(95% CI)

Cases ( n )

OR

(95% CI)

Never users

4,632

862

1.00

Reference

429

1.00

Reference

Ever users

5,415

990

1.15

(1.02 to 1.28)

615

1.24

(1.07 to 1.43)

OC recency

       

  < 5 years ago

1,075

183

1.46

(1.18 to 1.81)

131

1.57

(1.22 to 2.03)

 5 to 9 years ago

544

84

1.16

(0.89 to 1.52)

64

1.33

(0.97 to 1.82)

 10 to 14 years ago

595

105

1.25

(0.98 to 1.60)

64

1.12

(0.82 to 1.52)

 15 to 19 years ago

757

153

1.28

(1.04 to 1.58)

92

1.14

(0.88 to 1.48)

 20 to 24 years ago

859

148

1.01

(0.82 to 1.24)

97

1.07

(0.83 to 1.37)

 25 to 29 years ago

781

123

0.93

(0.75 to 1.15)

91

1.41

(1.09 to 1.81)

  ≥ 30 years ago

795

185

1.14

(0.94 to 1.38)

71

1.14

(0.85 to 1.51)

  P trend

  

<0.01

 

0.05

OC duration

       

  < 5 years

2,315

367

1.03

(0.89 to 1.19)

260

1.21

(1.01 to 1.44)

 5 to 9 years

1,629

321

1.25

(1.07 to 1.46)

160

1.07

(0.87 to 1.32)

 10 to 14 years

1,010

209

1.35

(1.12 to 1.61)

121

1.43

(1.13 to 1.80)

  ≥ 15 years

458

89

0.98

(0.76 to 1.27)

73

1.54

(1.15 to 2.06)

  P trend

  

0.13

 

0.05

Joint OC exposure (recency and duration)

      

Since last use

Duration

       

< 5 years

< 5 years

329

39

1.13

(0.78 to 1.62)

30

1.20

(0.78 to 1.83)

 

5 to 9 years

289

45

1.60

(1.12 to 2.28)

33

1.67

(1.10 to 2.53)

 

≥ 10 years

457

99

1.65

(1.27 to 2.15)

68

1.73

(1.26 to 2.37)

5 to 9 years

< 5 years

172

22

1.21

(0.75 to 1.94)

16

1.26

(0.72 to 2.21)

 

5 to 9 years

140

30

1.62

(1.05 to 2.52)

13

0.94

(0.51 to 1.74)

 

≥ 10 years

232

32

0.92

(0.62 to 1.38)

35

1.59

(1.06 to 2.38)

10 to 19 years

< 5 years

466

66

1.09

(0.82 to 1.47)

58

1.21

(0.87 to 1.67)

 

5 to 9 years

451

87

1.33

(1.02 to 1.73)

46

0.94

(0.66 to 1.33)

 

≥ 10 years

435

105

1.41

(1.11 to 1.81)

52

1.24

(0.90 to 1.72)

≥ 20 years

< 5 years

1,344

238

1.02

(0.86 to 1.20)

155

1.23

(1.00 to 1.51)

 

5 to 9 years

748

157

1.13

(0.92 to 1.38)

65

1.00

(0.75 to 1.33)

 

≥ 10 years

340

61

0.88

(0.65 to 1.19)

39

1.50

(1.03 to 2.17)

  1. CI, confidence interval; ER, estrogen receptor; OC, oral contraceptive; OR, odds ratio. aORs adjusted for age, study, time period, geographic region, education, age at menarche, parity, age at first birth, lactation, first-degree family history of breast cancer, menopausal status and age at menopause, duration of female hormone use, body mass index, alcohol consumption, and pack-years of cigarette smoking. P trend does not include never users.
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Breast Cancer Research

ISSN: 1465-542X

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