TY - JOUR AU - Heiser, L. M. AU - Sadanandam, A. AU - Kuo, W. L. AU - Benz, S. C. AU - Goldstein, T. C. AU - Ng, S. PY - 2012 DA - 2012// TI - Subtype and pathway specific responses to anticancer compounds in breast cancer JO - Proc Natl Acad Sci USA VL - 109 UR - https://doi.org/10.1073/pnas.1018854108 DO - 10.1073/pnas.1018854108 ID - Heiser2012 ER - TY - JOUR AU - Eroles, P. AU - Bosch, A. AU - Perez-Fidalgo, J. A. AU - Lluch, A. PY - 2012 DA - 2012// TI - Molecular biology in breast cancer: intrinsic subtypes and signaling pathways JO - Cancer Treat Rev. VL - 38 UR - https://doi.org/10.1016/j.ctrv.2011.11.005 DO - 10.1016/j.ctrv.2011.11.005 ID - Eroles2012 ER - TY - JOUR AU - Al-Ejeh, F. AU - Shi, W. AU - Miranda, M. AU - Simpson, P. T. AU - Vargas, A. C. AU - Song, S. PY - 2013 DA - 2013// TI - Treatment of triple-negative breast cancer using anti-EGFR-directed radioimmunotherapy combined with radiosensitizing chemotherapy and PARP inhibitor JO - J Nucl Med. VL - 54 UR - https://doi.org/10.2967/jnumed.112.111534 DO - 10.2967/jnumed.112.111534 ID - Al-Ejeh2013 ER - TY - JOUR AU - Farmer, H. AU - McCabe, N. AU - Lord, C. J. AU - Tutt, A. N. AU - Johnson, D. A. AU - Richardson, T. B. PY - 2005 DA - 2005// TI - Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy JO - Nature. VL - 434 UR - https://doi.org/10.1038/nature03445 DO - 10.1038/nature03445 ID - Farmer2005 ER - TY - JOUR AU - Tutt, A. AU - Robson, M. AU - Garber, J. E. AU - Domchek, S. M. AU - Audeh, M. W. AU - Weitzel, J. N. PY - 2010 DA - 2010// TI - Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial JO - Lancet. VL - 376 UR - https://doi.org/10.1016/S0140-6736(10)60892-6 DO - 10.1016/S0140-6736(10)60892-6 ID - Tutt2010 ER - TY - JOUR AU - Bryant, H. E. AU - Schultz, N. AU - Thomas, H. D. AU - Parker, K. M. AU - Flower, D. AU - Lopez, E. PY - 2005 DA - 2005// TI - Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase JO - Nature. VL - 434 UR - https://doi.org/10.1038/nature03443 DO - 10.1038/nature03443 ID - Bryant2005 ER - TY - JOUR AU - Fong, P. C. AU - Boss, D. S. AU - Yap, T. A. AU - Tutt, A. AU - Wu, P. AU - Mergui-Roelvink, M. PY - 2009 DA - 2009// TI - Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers JO - N Engl J Med. VL - 361 UR - https://doi.org/10.1056/NEJMoa0900212 DO - 10.1056/NEJMoa0900212 ID - Fong2009 ER - TY - JOUR AU - Audeh, M. W. AU - Carmichael, J. AU - Penson, R. T. AU - Friedlander, M. AU - Powell, B. AU - Bell-McGuinn, K. M. PY - 2010 DA - 2010// TI - Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial JO - Lancet. VL - 376 UR - https://doi.org/10.1016/S0140-6736(10)60893-8 DO - 10.1016/S0140-6736(10)60893-8 ID - Audeh2010 ER - TY - JOUR AU - Chuang, H. C. AU - Kapuriya, N. AU - Kulp, S. K. AU - Chen, C. S. AU - Shapiro, C. L. PY - 2012 DA - 2012// TI - Differential anti-proliferative activities of poly(ADP-ribose) polymerase (PARP) inhibitors in triple-negative breast cancer cells JO - Breast Cancer Res Treat. VL - 134 UR - https://doi.org/10.1007/s10549-012-2106-5 DO - 10.1007/s10549-012-2106-5 ID - Chuang2012 ER - TY - JOUR AU - McCabe, N. PY - 2006 DA - 2006// TI - Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-Ribose) polymerase inhibition JO - Cancer Res. VL - 66 UR - https://doi.org/10.1158/0008-5472.CAN-06-0140 DO - 10.1158/0008-5472.CAN-06-0140 ID - McCabe2006 ER - TY - JOUR AU - Eot-Houllier, G. AU - Fulcrand, G. AU - Magnaghi-Jaulin, L. AU - Jaulin, C. PY - 2009 DA - 2009// TI - Histone deacetylase inhibitors and genomic instability JO - Cancer Lett. VL - 274 UR - https://doi.org/10.1016/j.canlet.2008.06.005 DO - 10.1016/j.canlet.2008.06.005 ID - Eot-Houllier2009 ER - TY - JOUR AU - Kim, I. A. AU - Kim, J. H. AU - Shin, J. H. AU - Kim, I. H. AU - Kim, J. S. AU - Wu, H. G. PY - 2005 DA - 2005// TI - A histone deacetylase inhibitor, trichostatin A, enhances radiosensitivity by abrogating G2/M arrest in human carcinoma cells JO - Cancer Res Treat. VL - 37 UR - https://doi.org/10.4143/crt.2005.37.2.122 DO - 10.4143/crt.2005.37.2.122 ID - Kim2005 ER - TY - JOUR AU - Adimoolam, S. AU - Sirisawad, M. AU - Chen, J. AU - Thiemann, P. AU - Ford, J. M. AU - Buggy, J. J. PY - 2007 DA - 2007// TI - HDAC inhibitor PCI-24781 decreases RAD51 expression and inhibits homologous recombination JO - Proc Natl Acad Sci USA VL - 104 UR - https://doi.org/10.1073/pnas.0707828104 DO - 10.1073/pnas.0707828104 ID - Adimoolam2007 ER - TY - JOUR AU - Kachhap, S. K. AU - Rosmus, N. AU - Collis, S. J. AU - Kortenhorst, M. S. AU - Wissing, M. D. AU - Hedayati, M. PY - 2010 DA - 2010// TI - Downregulation of homologous recombination DNA repair genes by HDAC inhibition in prostate cancer is mediated through the E2F1 transcription factor JO - PLoS One. VL - 5 UR - https://doi.org/10.1371/journal.pone.0011208 DO - 10.1371/journal.pone.0011208 ID - Kachhap2010 ER - TY - JOUR AU - Weberpals, J. I. AU - O'Brien, A. M. AU - Niknejad, N. AU - Garbuio, K. D. AU - Clark-Knowles, K. V. AU - Dimitroulakos, J. PY - 2011 DA - 2011// TI - The effect of the histone deacetylase inhibitor M344 on BRCA1 expression in breast and ovarian cancer cells JO - Cancer Cell Int. VL - 11 UR - https://doi.org/10.1186/1475-2867-11-29 DO - 10.1186/1475-2867-11-29 ID - Weberpals2011 ER - TY - JOUR AU - Lee, C. K. AU - Wang, S. AU - Huang, X. AU - Ryder, J. AU - Liu, B. PY - 2010 DA - 2010// TI - HDAC inhibition synergistically enhances alkylator-induced DNA damage responses and apoptosis in multiple myeloma cells JO - Cancer Lett. VL - 296 UR - https://doi.org/10.1016/j.canlet.2010.04.014 DO - 10.1016/j.canlet.2010.04.014 ID - Lee2010 ER - TY - JOUR AU - Luszczek, W. AU - Cheriyath, V. AU - Mekhail, T. M. AU - Borden, E. C. PY - 2010 DA - 2010// TI - Combinations of DNA methyltransferase and histone deacetylase inhibitors induce DNA damage in small cell lung cancer cells: correlation of resistance with IFN-stimulated gene expression JO - Mol Cancer Ther. VL - 9 UR - https://doi.org/10.1158/1535-7163.MCT-10-0309 DO - 10.1158/1535-7163.MCT-10-0309 ID - Luszczek2010 ER - TY - JOUR AU - Zhang, J. X. AU - Li, D. Q. AU - He, A. R. AU - Motwani, M. AU - Vasiliou, V. AU - Eswaran, J. PY - 2012 DA - 2012// TI - Synergistic inhibition of hepatocellular carcinoma growth by cotargeting chromatin modifying enzymes and poly (ADP-ribose) polymerases JO - Hepatology. VL - 55 UR - https://doi.org/10.1002/hep.25566 DO - 10.1002/hep.25566 ID - Zhang2012 ER - TY - JOUR AU - Min, A. AU - Im, S. A. AU - Yoon, Y. K. AU - Song, S. H. AU - Nam, H. J. AU - Hur, H. S. PY - 2013 DA - 2013// TI - RAD51C-Deficient cancer cells are highly sensitive to the PARP inhibitor olaparib JO - Mol Cancer Ther. VL - 12 UR - https://doi.org/10.1158/1535-7163.MCT-12-0950 DO - 10.1158/1535-7163.MCT-12-0950 ID - Min2013 ER - TY - JOUR AU - Chou, T. C. PY - 2010 DA - 2010// TI - Drug combination studies and their synergy quantification using the Chou-Talalay method JO - Cancer Res. VL - 70 UR - https://doi.org/10.1158/0008-5472.CAN-09-1947 DO - 10.1158/0008-5472.CAN-09-1947 ID - Chou2010 ER - TY - JOUR AU - Robert, T. AU - Vanoli, F. AU - Chiolo, I. AU - Shubassi, G. AU - Bernstein, K. A. AU - Rothstein, R. PY - 2011 DA - 2011// TI - HDACs link the DNA damage response, processing of double-strand breaks and autophagy JO - Nature. VL - 471 UR - https://doi.org/10.1038/nature09803 DO - 10.1038/nature09803 ID - Robert2011 ER - TY - JOUR AU - Namdar, M. AU - Perez, G. AU - Ngo, L. AU - Marks, P. A. PY - 2010 DA - 2010// TI - Selective inhibition of histone deacetylase 6 (HDAC6) induces DNA damage and sensitizes transformed cells to anticancer agents JO - Proc Natl Acad Sci USA VL - 107 UR - https://doi.org/10.1073/pnas.1013754107 DO - 10.1073/pnas.1013754107 ID - Namdar2010 ER - TY - JOUR AU - Pettazzoni, P. AU - Pizzimenti, S. AU - Toaldo, C. AU - Sotomayor, P. AU - Tagliavacca, L. AU - Liu, S. PY - 2011 DA - 2011// TI - Induction of cell cycle arrest and DNA damage by the HDAC inhibitor panobinostat (LBH589) and the lipid peroxidation end product 4-hydroxynonenal in prostate cancer cells JO - Free Radic Biol Med. VL - 50 UR - https://doi.org/10.1016/j.freeradbiomed.2010.11.011 DO - 10.1016/j.freeradbiomed.2010.11.011 ID - Pettazzoni2011 ER - TY - JOUR AU - Shubassi, G. AU - Robert, T. AU - Vanoli, F. AU - Minucci, S. AU - Foiani, M. PY - 2012 DA - 2012// TI - Acetylation: a novel link between double-strand break repair and autophagy JO - Cancer Res. VL - 72 UR - https://doi.org/10.1158/0008-5472.CAN-11-3172 DO - 10.1158/0008-5472.CAN-11-3172 ID - Shubassi2012 ER - TY - JOUR AU - Koprinarova, M. AU - Botev, P. AU - Russev, G. PY - 2011 DA - 2011// TI - Histone deacetylase inhibitor sodium butyrate enhances cellular radiosensitivity by inhibiting both DNA nonhomologous end joining and homologous recombination JO - DNA Repair (Amst). VL - 10 UR - https://doi.org/10.1016/j.dnarep.2011.07.003 DO - 10.1016/j.dnarep.2011.07.003 ID - Koprinarova2011 ER - TY - JOUR AU - Shiloh, Y. AU - Lehmann, A. R. PY - 2004 DA - 2004// TI - Maintaining integrity JO - Nat Cell Biol. VL - 6 UR - https://doi.org/10.1038/ncb1004-923 DO - 10.1038/ncb1004-923 ID - Shiloh2004 ER - TY - JOUR AU - Carden, C. P. AU - Yap, T. A. AU - Kaye, S. B. PY - 2010 DA - 2010// TI - PARP inhibition: targeting the Achilles’ heel of DNA repair to treat germline and sporadic ovarian cancers JO - Curr Opin Oncol. VL - 22 UR - https://doi.org/10.1097/CCO.0b013e32833b5126 DO - 10.1097/CCO.0b013e32833b5126 ID - Carden2010 ER - TY - JOUR AU - Weston, V. J. AU - Oldreive, C. E. AU - Skowronska, A. AU - Oscier, D. G. AU - Pratt, G. AU - Dyer, M. J. PY - 2010 DA - 2010// TI - The PARP inhibitor olaparib induces significant killing of ATM-deficient lymphoid tumor cells in vitro and in vivo JO - Blood. VL - 116 UR - https://doi.org/10.1182/blood-2010-01-265769 DO - 10.1182/blood-2010-01-265769 ID - Weston2010 ER - TY - JOUR AU - Johnson, N. AU - Li, Y. -. C. AU - Walton, Z. E. AU - Cheng, K. A. AU - Li, D. AU - Rodig, S. J. PY - 2011 DA - 2011// TI - Compromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibition JO - Nat Med. VL - 17 UR - https://doi.org/10.1038/nm.2377 DO - 10.1038/nm.2377 ID - Johnson2011 ER - TY - JOUR AU - Yap, T. A. AU - Sandhu, S. K. AU - Carden, C. P. AU - Bono, J. S. PY - 2011 DA - 2011// TI - Poly(ADP-ribose) polymerase (PARP) inhibitors: exploiting a synthetic lethal strategy in the clinic JO - CA Cancer J Clin. VL - 61 UR - https://doi.org/10.3322/caac.20095 DO - 10.3322/caac.20095 ID - Yap2011 ER - TY - JOUR AU - Thurn, K. T. AU - Thomas, S. AU - Raha, P. AU - Qureshi, I. AU - Munster, P. N. PY - 2013 DA - 2013// TI - Histone deacetylase regulation of ATM-mediated DNA damage signaling JO - Mol Cancer Ther. VL - 12 UR - https://doi.org/10.1158/1535-7163.MCT-12-1242 DO - 10.1158/1535-7163.MCT-12-1242 ID - Thurn2013 ER - TY - JOUR AU - Ha, K. AU - Fiskus, W. AU - Choi, D. S. AU - Bhaskara, S. AU - Cerchietti, L. AU - Devaraj, S. G. PY - 2014 DA - 2014// TI - Histone deacetylase inhibitor treatment induces ‘BRCAness’ and synergistic lethality with PARP inhibitor and cisplatin against human triple negative breast cancer cells JO - Oncotarget. VL - 5 UR - https://doi.org/10.18632/oncotarget.2154 DO - 10.18632/oncotarget.2154 ID - Ha2014 ER - TY - JOUR AU - Mendes-Pereira, A. M. AU - Martin, S. AU - Brough, R. AU - McCarthy, A. AU - Taylor, J. R. AU - Kim, J. -. S. PY - 2009 DA - 2009// TI - Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors JO - EMBO Mol Med. VL - 1 UR - https://doi.org/10.1002/emmm.200900041 DO - 10.1002/emmm.200900041 ID - Mendes-Pereira2009 ER - TY - JOUR AU - Kimbung, S. AU - Biskup, E. AU - Johansson, I. AU - Aaltonen, K. AU - Ottosson-Wadlund, A. AU - Gruvberger-Saal, S. PY - 2012 DA - 2012// TI - Co-targeting of the PI3K pathway improves the response of BRCA1 deficient breast cancer cells to PARP1 inhibition JO - Cancer Lett. VL - 319 UR - https://doi.org/10.1016/j.canlet.2012.01.015 DO - 10.1016/j.canlet.2012.01.015 ID - Kimbung2012 ER - TY - JOUR AU - Hale, A. N. AU - Ledbetter, D. J. AU - Gawriluk, T. R. AU - Rucker, E. B. PY - 2013 DA - 2013// TI - Autophagy: regulation and role in development JO - Autophagy. VL - 9 UR - https://doi.org/10.4161/auto.24273 DO - 10.4161/auto.24273 ID - Hale2013 ER - TY - JOUR AU - Bincoletto, C. AU - Bechara, A. AU - Pereira, G. J. AU - Santos, C. P. AU - Antunes, F. PY - 2013 DA - 2013// TI - Peixoto da-Silva J, et al. Interplay between apoptosis and autophagy, a challenging puzzle: New perspectives on antitumor chemotherapies JO - Chem Biol Interact VL - 206 UR - https://doi.org/10.1016/j.cbi.2013.09.018 DO - 10.1016/j.cbi.2013.09.018 ID - Bincoletto2013 ER - TY - JOUR AU - Gewirtz, D. A. PY - 2013 DA - 2013// TI - Cytoprotective and nonprotective autophagy in cancer therapy JO - Autophagy VL - 9 UR - https://doi.org/10.4161/auto.25233 DO - 10.4161/auto.25233 ID - Gewirtz2013 ER - TY - JOUR AU - True, O. AU - Matthias, P. PY - 2012 DA - 2012// TI - Interplay between histone deacetylases and autophagy–from cancer therapy to neurodegeneration JO - Immunol Cell Biol. VL - 90 UR - https://doi.org/10.1038/icb.2011.103 DO - 10.1038/icb.2011.103 ID - True2012 ER - TY - JOUR AU - Sui, X. AU - Chen, R. AU - Wang, Z. AU - Huang, Z. AU - Kong, N. AU - Zhang, M. PY - 2013 DA - 2013// TI - Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment JO - Cell Death Dis. VL - 4 UR - https://doi.org/10.1038/cddis.2013.350 DO - 10.1038/cddis.2013.350 ID - Sui2013 ER -