Table 4 Mulivariate Cox proportional hazard model using standardized mean values for the gene signatures as variables

Gene signature 1

1.790

1.205-2.659

0.00392

Gene signature 5

0.6210

0.4201-0.9177

0.0168

Gene signature 12

0.3085

0.1592-0.5977

0.000492

Gene signature 13

3.327

1.743-6.353

0.000270

Gene signature 1

1.870

1.20-2.91

0.00535

Gene signature 5

0.5847

0.371-0.922

0.0209

Gene signature 12

0.2685

0.115-0.630

0.00250

Gene signature 13

3.238

1.47-7.13

0.00353

Tumor size

1.158

0.384-3.49

0.794

Node status

3.603

1.33-9.74

0.0115

Estrogen receptor

2.928

1.40-6.14

0.00446

Gene signature 1

2.099

1.35-3.27

0.00103

Gene signature 5

0.6650

0.437-1.01

0.0569

Gene signature 12

0.3118

0.147-0.662

0.00242

Gene signature 13

3.026

1.52-6.01

0.00158

Node status

4.578

2.07-10.1

0.000175

Gene signature 12

0.3016

0.1686-0.5394

0.0000532

Gene signature 13

3.406

1.860-6.235

0.0000713

Gene signature 12

0.2573

0.128-0.518

0.000140

Gene signature 13

3.451

1.77-6.73

0.000278

Tumor size

0.9399

0.311-2.84

0.913

Node status

3.905

1.43-10.7

0.00785

Estrogen receptor

2.842

1.37-5.89

0.00498

Gene signature 12

0.3576

0.1873-0.6827

0.00183

Gene signature 13

2.759

1.470-5.179

0.00159

Node status

4.533

2.563-9.994

0.000179