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Table 2 List of major tumor suppressive microRNAs in breast cancer

From: Dysregulation of microRNAs in breast cancer and their potential role as prognostic and predictive biomarkers in patient management

miRNA Target Function Number of samples a Reference
miR-125b EPO, EPOR Inhibits cell proliferation and differentiation n = 42 [29]
  ENPEP, CK2-α,CCNJ, MEGF9 Inhibits cell proliferation n = 25 [30]
  ERBB2 Inhibits migration and invasion Cell line study [31]
miR-205 HMGB3 Suppresses proliferation and invasion n = 20 [32,33]
miR-17-92 Mekk2 Promotes NK cell antitumoral activity and reduces metastasis n = 20 [34,35]
miR-206 Cyclin D2, Cx43 Reduces migration, invasion and metastasis n = 128 [36,37]
miR-200 ZEB1/2, SNAI1/2 Reduces tumor growth, metastasis and EMT n = 70 [38-40]
miR-146b NFkB, STAT3 Reduces survival and metastasis n = 91 [41,42]
miR-126 IGFBP2, MERTK,PITPNC1 Reduces metastasis and angiogenesis n = 117, n = 295 [43]
  No specific targets listed Reduces tumorigenesis and metastasis Cell line study [44]
miR-335 SOX4, TNC Suppresses metastasis and migration n = 20 [44,45]
miR-31 RhoA Inhibits several steps of the invasion-metastasis cascade in breast cancer n = 54 [46]
  WAVE3, RhoA Reduces cancer progression and metastasis Cell line study [47]
  WAVE3 Reduces cancer progression and metastasis n = 19 [48]
  1. Metastasis-suppressive miRs are indicated in bold. aWhen applying more than one reference, we focused on the study with the most relevant number of investigated patient samples. The other studies serve as validation and confirm the results. CCNJ, cyclin J; CK2-α, casein kinase 2-alpha; Cx43, connexin 43; ENPEP, glutamylaminopeptidase or aminopeptidase A; EPO, erythropoietin; EPOR, erythropoietin receptor; ERBB2, Receptor tyrosine-protein kinase erbB-2 (human epidermal growth factor receptor 2); HMGB3, high-mobility group box 3 gene; IGFBP2, insulin-like growth factor-binding protein 2; MEGF9, multiple EGF-like domains 9; Mekk2, mitogen-activated protein kinase kinase kinase 2; MERTK, c-Mer tyrosine kinase; miRNA, microRNA; NFkB, nuclear factor kappa B; NK, natural killer; PITPNC1, phosphatidylinositol transfer protein, cytoplasmic 1; RhoA, Ras homolog gene family; SNAI1/2, snail family zinc finger 1/2; SOX4, SRY-related HMG-box 4; STAT3, signal transducer and activator of transcription 3; TNC, tenascin C; WAVE3, WAS protein family, member 3; ZEB1/2, zinc finger E-box binding homeobox 1/2.