Dysregulation of microRNAs in breast cancer and their potential role as prognostic and predictive biomarkers in patient management

Table 2 List of major tumor suppressive microRNAs in breast cancer

miRNA	Target	Function	Number of samples ^a	Reference
miR-125b	EPO, EPOR	Inhibits cell proliferation and differentiation	n = 42	[29]
	ENPEP, CK2-α,CCNJ, MEGF9	Inhibits cell proliferation	n = 25	[30]
	ERBB2	Inhibits migration and invasion	Cell line study	[31]
miR-205	HMGB3	Suppresses proliferation and invasion	n = 20	[32,33]
miR-17-92	Mekk2	Promotes NK cell antitumoral activity and reduces metastasis	n = 20	[34,35]
miR-206	Cyclin D2, Cx43	Reduces migration, invasion and metastasis	n = 128	[36,37]
miR-200	ZEB1/2, SNAI1/2	Reduces tumor growth, metastasis and EMT	n = 70	[38-40]
miR-146b	NFkB, STAT3	Reduces survival and metastasis	n = 91	[41,42]
miR-126	IGFBP2, MERTK,PITPNC1	Reduces metastasis and angiogenesis	n = 117, n = 295	[43]
	No specific targets listed	Reduces tumorigenesis and metastasis	Cell line study	[44]
miR-335	SOX4, TNC	Suppresses metastasis and migration	n = 20	[44,45]
miR-31	RhoA	Inhibits several steps of the invasion-metastasis cascade in breast cancer	n = 54	[46]
	WAVE3, RhoA	Reduces cancer progression and metastasis	Cell line study	[47]
	WAVE3	Reduces cancer progression and metastasis	n = 19	[48]

Metastasis-suppressive miRs are indicated in bold. ^aWhen applying more than one reference, we focused on the study with the most relevant number of investigated patient samples. The other studies serve as validation and confirm the results. CCNJ, cyclin J; CK2-α, casein kinase 2-alpha; Cx43, connexin 43; ENPEP, glutamylaminopeptidase or aminopeptidase A; EPO, erythropoietin; EPOR, erythropoietin receptor; ERBB2, Receptor tyrosine-protein kinase erbB-2 (human epidermal growth factor receptor 2); HMGB3, high-mobility group box 3 gene; IGFBP2, insulin-like growth factor-binding protein 2; MEGF9, multiple EGF-like domains 9; Mekk2, mitogen-activated protein kinase kinase kinase 2; MERTK, c-Mer tyrosine kinase; miRNA, microRNA; NFkB, nuclear factor kappa B; NK, natural killer; PITPNC1, phosphatidylinositol transfer protein, cytoplasmic 1; RhoA, Ras homolog gene family; SNAI1/2, snail family zinc finger 1/2; SOX4, SRY-related HMG-box 4; STAT3, signal transducer and activator of transcription 3; TNC, tenascin C; WAVE3, WAS protein family, member 3; ZEB1/2, zinc finger E-box binding homeobox 1/2.

ISSN: 1465-542X