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Table 1 List of major oncogenic microRNAs in breast cancer

From: Dysregulation of microRNAs in breast cancer and their potential role as prognostic and predictive biomarkers in patient management

miRNA Target Function Number of samples a Reference
miR-10b HOXD10 Promotes cell migration, invasion and metastasis n = 23 [8,16,17]
miR-21 PDCD4, HIF1A Promotes invasion, metastasis, migration and EMT Cell culture study [18,19,22]
  TPM1, PTEN, PDCD4 Promotes invasion n = 17 [20]
  TIMP3 Promotes invasion n = 32 [21]
miR-155 SOCS1 Promotes cell growth and proliferation n = 15 [23]
  TP53INP1 Promotes proliferation Cell culture study [24]
  FOXO3 Promotes proliferation and survival n = 115 [25]
miR-373 CD44 Promotes cell migration and invasion n = 11 [26]
Promotes invasion and metastasis Cell culture study [27]
miR-520c CD44 Promotes cell migration, invasion and metastasis n = 11 [26]
  1. MetastamiRs are indicated in bold. aWhen applying more than one reference, we focused on the study with the most relevant number of investigated patient samples. The other studies serve as validation and confirm the results. EMT, epithelial-to-mesenchymal transition; FOXO3, forkhead box protein O3; HIF1A, hypoxia-inducible factor-1α; HOXD10, homeobox D10; miRNA, microRNA; PDCD4, programmed cell death protein 4; PTEN, phosphatase and tensin homolog; SOCS1, suppressor of cytokine signaling 1; TIMP3, metalloproteinase inhibitor 3; TM1, tropomyosine 1; TP53INP, tumor protein p53 inducible nuclear protein.