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Table 1 Characteristics of breast cancer cell lines

From: Preclinical evaluation of cyclin dependent kinase 11 and casein kinase 2 survival kinases as RNA interference targets for triple negative breast cancer therapy

Cell line a Transformed Molecular subtype Histological pathology b ER expressed PR expressed Her2 amplified
MCF-10A No Basal Fibrocystic No No No
MCF-12A No Basal Fibrocystic No No No
BT-474 Yes Luminal B DC Yes Yes Yes
MCF-7 Yes Luminal A AC Yes Yes No
MCF-7LTamR Yes Luminal A AC Yes Yes No
MDA-MB-231 Yes Basal AC No No No
MDA-MB-468 Yes Basal AC No No No
SUM-149 Yes Basal IBC No No No
SUM-190 Yes Basal IBC No No Yes
  1. AC, adenocarcinoma; DC, ductal carcinoma; ER, estrogen receptor; IBC, inflammatory breast cancer; PR, progesterone receptor; Her2, human epidermal growth factor receptor 2. aMCF-10A and MCF-12A are spontaneously immortalized cells. bOriginal tissue or tumor.