Skip to main content

Table 2 TGFBR2 and IL12B SNPs associated with overall survival ( P -value <0.001) in ER-negative patients with chemotherapy

From: Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with prognosis of estrogen receptor-negative breast cancer after chemotherapy

Chr

Gene

SNP

Minor allele

MAF

ER-negative patients who received adjuvant chemotherapy

ER-negative patients who did not receive adjuvant chemotherapy

ER-positive patients who received adjuvant chemotherapy

Cases, number

Events, number

HR a (95% CI)

P -value

Cases, number

Events, number

HR a (95% CI)

P -value

P heterogeneity b

Cases, number

Events, number

HR a (95% CI)

P -value

P heterogeneity c

3

TGFBR2

rs1367610

C

0.14

1499

267

1.54 (1.22, 1.95)

3.08 × 10−4

834

155

0.78 (0.55, 1.13)

0.191

8.82 × 10−4

3151

376

0.88 (0.70, 1.10)

0.251

2.62 × 10−4

5

IL12B

rs2546892

A

0.17

1499

267

1.50 (1.21, 1.86)

1.81 × 10−4

835

155

0.99 (0.74, 1.33)

0.968

0.025

3151

376

0.99 (0.82, 1.20)

0.940

4.63 × 10−3

5

IL12B

rs2853694

C

0.51

1499

267

0.73 (0.61, 0.87)

3.67 × 10−4

835

155

1.06 (0.85, 1.33)

0.596

0.020

3151

376

0.95 (0.82, 1.10)

0.529

0.023

  1. aHR adjusted for age of diagnosis, tumor size, tumor grade, node status and nine principal components to account for population substructure and stratified by study. b P-value for test of heterogeneity between ER-negative breast cancer patients who received adjuvant chemotherapy and ER-negative breast cancer patients who did not receive adjuvant chemotherapy. c P-value for test of heterogeneity between ER-negative breast cancer patients who received adjuvant chemotherapy and ER-positive breast cancer patients who received adjuvant chemotherapy. TGFBR2, transforming growth factor, beta receptor II; SNP, single nucleotide polymorphism; ER, estrogen receptor; Chr, chromosome; MAF, minor allele frequency; HR, hazard ratio; IL12B, interleukin 12B; and CI, confidence interval.
Back to article page

Breast Cancer Research

ISSN: 1465-542X

Contact us