Table 1 Recurrent mutations in invasive lobular carcinoma
From: Invasive lobular carcinoma of the breast: morphology, biomarkers and ’omics
Gene | Ellis et al. [38] (n = ~40) a | Ross et al. [62] (n = 22) b | |
|---|---|---|---|
AKT1 | 0.6% | NR | 9.1% |
ARID1A | 4.5% | NR | NA |
ATR | 2.0% | 2.5% | NA |
BIRC6 | 2.0% | 2.5% | NA |
CDH1 | 50.0% | 50.0% | 100% |
CDKN1B | 1.3% | 3.4% | NA |
ERBB2 | 3.8% | NR | 18% |
GATA3 | 2.6% | 3.4% | NA |
KRAS | 0.6% | NR | 9.1% |
MALAT1 | 0.0% | 2.5% | NA |
MAP2K4 | 0.6% | 3.4% | 9.1% |
MAP3K1 | 5.0% | 13.8% | NA |
NCOR1 | 4.5% | 9.1% | NA |
NF1 | 3.2% | NR | NA |
PIK3CA | 41.0% | 41.4% | 36.4% |
RB1 | 1.30% | 0 | 9.1% |
RUNX1 | 7.0% | 5.0% | 4.5% |
SMAD4 | 1.30% | NR | NA |
TP53 | 5.0% | 12.1% | 36.4% |