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Table 1 Recurrent mutations in invasive lobular carcinoma

From: Invasive lobular carcinoma of the breast: morphology, biomarkers and ’omics

Gene cBioPortal [30,31] (n = 155) Ellis et al. [38] (n = ~40) a Ross et al. [62] (n = 22) b
AKT1 0.6% NR 9.1%
ARID1A 4.5% NR NA
ATR 2.0% 2.5% NA
BIRC6 2.0% 2.5% NA
CDH1 50.0% 50.0% 100%
CDKN1B 1.3% 3.4% NA
ERBB2 3.8% NR 18%
GATA3 2.6% 3.4% NA
KRAS 0.6% NR 9.1%
MALAT1 0.0% 2.5% NA
MAP2K4 0.6% 3.4% 9.1%
MAP3K1 5.0% 13.8% NA
NCOR1 4.5% 9.1% NA
NF1 3.2% NR NA
PIK3CA 41.0% 41.4% 36.4%
RB1 1.30% 0 9.1%
RUNX1 7.0% 5.0% 4.5%
SMAD4 1.30% NR NA
TP53 5.0% 12.1% 36.4%
  1. aThe exact number of invasive lobular carcinomas in the Ellis study is difficult to define as several cohorts were assessed using a variety of technologies. bThe Ross study selected only CDH1 mutant cases. NA, not available; NR, not reported.