Genomic architecture of invasive lobular carcinoma. (A) CIRCOS plot of an invasive lobular carcinoma (ILC) tumour profiled using the Illumina Omni 2.5 million SNP CNV array. Note the archetypal ILC changes, including chromosome 1q gain, 8p amplification, 11q13 amplification and 16q deletion. (B) Spectrum of somatic mutations across the E-cadherin coding region in the cBioPortal ILC data set [30,31]. Note the cadherin prodomain in green and the cadherin cytoplasmic domain in blue; missense mutations in green and nonsense mutations in red. (C) Oncoprint depicting the frequency of somatic mutations in key, recurrently altered cancer genes (CDH1, TP53, PIK3CA, ERBB2) affecting 75% of the 155 ILCs in The Cancer Genome Atlas cohort [30,31]. Percentages are numbers of tumours exhibiting an alteration in the specified gene.