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Figure 2 | Breast Cancer Research

Figure 2

From: Mammary gland tumor promotion by chronic administration of IGF1 and the insulin analogue AspB10 in the p53R270H/+WAPCre mouse model

Figure 2

Insulin analogues induce primarily EMT tumors in p53 R270H/+ WAPCre female mice. A) H & E images of representative EMT tumors with predominantly epithelial cells (left panel) and an EMT tumor with predominantly mesenchymal cells (right panel). B) Immunofluoresent images of CK5/8, area with normal mammary duct on the same slide that serves as control for CK5/CK8 staining, E-cadherin and smooth muscle actin. C) Tumor type distribution per treatment. D) Mammary gland tumor type distribution per treatment. E) Average number of mammary gland tumors. F) Percentage of epithelial cells in the EMT tumors over the different treatment groups. EMT, epithelial to mesenchymal transition.

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Breast Cancer Research

ISSN: 1465-542X

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