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Table 2 Genetically engineered mouse models related to infiltrating lobular breast cancer

From: Lobular breast cancer: molecular basis, mouse and cellular models

Promoter element Recombinase/transgene Targeted tissues Conditional knockout Tumors Tumor spectrum (mammary gland or stomach) References
Mammary gland      
MMTV Cre MGa, SALG, SV Cdh1 F/F No x [59]
K14 Cre MGa, SALG, EPD, ESO Cdh1 F/F No x [60]
K14 Cre MGa, SALG, EPD, ESO Cdh1 F/F No x [61]
WAP Cre MGa Cdh1 F/F No x [62]
WAP Cre MGa Cdh1 F/F No x [63]
K14 Cre MGa, SALG, EPD, ESO Cdh1 F/F ; Trp53 F/F Yes mILC (54%), CS (27%), sAC (23%) [61]
WAP Cre MGa Cdh1 F/F ; Trp53 F/F Yes mILC (60%), sC/CS (67%), AC (2%) [63]
Stomach       
 x Cdh1 +/− None x No x [57]
 x Cdh1 +/− (+MNU) None x Yes tubAd (75%), SRCC (45%) [57]
ATP4B Cre GPC Cdh1 F/F No (noninvasive signet ring cell clusters) [64]
ATP4B Cre GPC Cdh1 F/F ; Trp53 F/F Yes DGC [65]
PDX1 Cre GMC, DMC, PIC Cdh1 F/+ ; Smad4 F/F ; Trp53 F/F Yes DGC (85%, Ecad-negative), DDAC (26% Ecad-positive), SCC (24%) [66]
  1. All information compiled from the literature. AC, adenocarcinoma; CS, carcinosarcoma; DGC, diffuse gastric cancer; DDAC, duodenal adenocarcinoma; DMC, duodenal mucosal cells; Ecad, E-cadherin; EPD, epidermis; ESO, esophageal mucosa; GMC, gastric mucosal cells; GPC, gastric parietal cells; MG, mammary gland; mILC, murine infiltrating lobular carcinoma; MNU, carcinogenic N-methyl-N-nitrosourea given with the drinking water; sAC, solid adenocarcinoma; sC, solid carcinoma; PIC, pancreatic islet cells; SCC, squamous cell carcinoma; SALG, salivary gland; SRCC, signet ring cell carcinoma; SV, seminal vesicle; tubAd, tubular adenoma. aLuminal and myoepithelial cells in virgin and pregnant female mice.