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Table 3 Univariate and multivariate analyses of the prognostic value of miR-125b-5p, miR-205-5p and miR-424-3p expression levels and clinical parameters in relation to relapse-free survival a

From: MicroRNA-125b upregulation confers aromatase inhibitor resistance and is a novel marker of poor prognosis in breast cancer

  Number of samples Univariate Multivariate
HR (95% CI) P -value b HR (95% CI) P -value b
miR-125b-5p expression levels 65 6.80 (1.35 to 35.26) 0.009 6.35 (1.21 to 33.27) 0.029
miR-205-5p expression levels 65 1.86 (0.63 to 10.40) NS (0.17) ND ND
miR-424-3p expression levels 65 1.04 (0.52 to 7.58) NS (0.31) ND ND
Age (≤50 yr; >50 yr) 65 0.02 (0.54 to 2.03) NS (0.90) ND ND
Macroscopic tumor size (≤30 mm; >30 mm) 64c 1.47 (0.08 to 1.89) NS (0.22) ND ND
Lymph node status (≤3; >3) 65 7.68 (1.42 to 33.15) 0.006 6.29 (1.27 to 31.07) 0.024
Histological grade (SBR1 + SBR2; SBR3) 65 0.45 (0.35 to 8.18) NS (0.50) ND ND
Histological grade (SBR1; SBR2) 22 1.41 (0.01 to 3.49) NS (0.23) ND ND
Histological grade (SBR1; SBR3) 47 0.48 (0.06 to 4.00) NS (0.49) ND ND
Histological grade (SBR2; SBR3) 61 1.10 (0.36 to 23.68) NS (0.29) ND ND
ER status (negative; positive) 65 0.17 (0.20 to 2.85) NS (0.68) ND ND
PR status (negative; positive) 65 0.10 (0.21 to 3.04) NS (0.75) ND ND
HER2 status (negative; positive) 65 0.78 (0.48 to 6.84) NS (0.38) ND ND
  1. a95% CI, 95% confidence interval; ER, Estrogen receptor; HER2, Human epidermal growth factor receptor 2; HR, Hazard ratio; miR, MicroRNA; ND, Not done; NS, Not significant; PR, Progesterone receptor; SBR, Scarff-Bloom-Richardson grade. b P < 0.05 was considered significant. cInformation available for 64 patients.