Table 3 Univariate and multivariate analyses of the prognostic value of miR-125b-5p, miR-205-5p and miR-424-3p expression levels and clinical parameters in relation to relapse-free survival a
| Â | Number of samples | Univariate | Multivariate | ||
|---|---|---|---|---|---|
HR (95% CI) | P -value b | HR (95% CI) | P -value b | ||
miR-125b-5p expression levels | 65 | 6.80 (1.35 to 35.26) | 0.009 | 6.35 (1.21 to 33.27) | 0.029 |
miR-205-5p expression levels | 65 | 1.86 (0.63 to 10.40) | NS (0.17) | ND | ND |
miR-424-3p expression levels | 65 | 1.04 (0.52 to 7.58) | NS (0.31) | ND | ND |
Age (≤50 yr; >50 yr) | 65 | 0.02 (0.54 to 2.03) | NS (0.90) | ND | ND |
Macroscopic tumor size (≤30 mm; >30 mm) | 64c | 1.47 (0.08 to 1.89) | NS (0.22) | ND | ND |
Lymph node status (≤3; >3) | 65 | 7.68 (1.42 to 33.15) | 0.006 | 6.29 (1.27 to 31.07) | 0.024 |
Histological grade (SBR1 + SBR2; SBR3) | 65 | 0.45 (0.35 to 8.18) | NS (0.50) | ND | ND |
Histological grade (SBR1; SBR2) | 22 | 1.41 (0.01 to 3.49) | NS (0.23) | ND | ND |
Histological grade (SBR1; SBR3) | 47 | 0.48 (0.06 to 4.00) | NS (0.49) | ND | ND |
Histological grade (SBR2; SBR3) | 61 | 1.10 (0.36 to 23.68) | NS (0.29) | ND | ND |
ER status (negative; positive) | 65 | 0.17 (0.20 to 2.85) | NS (0.68) | ND | ND |
PR status (negative; positive) | 65 | 0.10 (0.21 to 3.04) | NS (0.75) | ND | ND |
HER2 status (negative; positive) | 65 | 0.78 (0.48 to 6.84) | NS (0.38) | ND | ND |