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Table 2 The top-ranked signaling pathways associated with resistance to aromatase inhibitors a

From: MicroRNA-125b upregulation confers aromatase inhibitor resistance and is a novel marker of poor prognosis in breast cancer

   Deregulation in Res-Let vs MCF-7aro Deregulation in Res-Ana vs MCF-7aro Convergence on the AKT pathway
KEGG pathway Pathway ID P -value b P -value b
Wnt signaling pathway hsa04310 7.1 × 10−9 7.0 × 10−7  
TGF-β signaling pathway hsa04350 2.1 × 10−8 3.0 × 10−4  
Axon guidance hsa04360 2.9 × 10−8 7.2 × 10−8  
Regulation of actin cytoskeleton hsa04810 1.0 × 10−7 1.5 × 10−5  
MAPK signaling pathway hsa04010 1.3 × 10−7 1.8 × 10−4 Yes
Focal adhesion hsa04510 3.0 × 10−7 8.2 × 10−10 Yes
Adherens junction hsa04520 2.0 × 10−6 2.4 × 10−6  
Insulin signaling pathway hsa04910 1.6 × 10−5 3.5 × 10−10 Yes
Ubiquitin-mediated proteolysis hsa04120 1.1 × 10−4 4.5 × 10−5  
ErbB signaling pathway hsa04012 1.3 × 10−4 4.5 × 10−6 Yes
Tight junction hsa04530 7.1 × 10−4 NP Yes
Phosphatidylinositol signaling system hsa04070 1.3 × 10−3 NP Yes
mTOR signaling pathway hsa04150 3.0 × 10−3 2.8 × 10−5 Yes
  1. aMAPK, Mitogen-activated protein kinase; mTOR, Mammalian target of rapamycin; NP, Not present in the top-ranked signaling pathways; TGF-β, Transforming growth factor β. b P-value was obtained using the DIANA-mirPath algorithm to identify significantly deregulated Kyoto Encyclopedia of Genes and Genomes (KEGG) signaling pathways predicted to be altered by the microRNAs selected in our study (Table 1).