
Total study population (
N
= 464)

Age 35 to 49 yr (
N
= 155)

Age ≥50 yr (
N
= 236)

White (
N
= 277)

Black (
N
= 145)


AUC

GOF
^{b}

P
value
^{c}

P
value
^{d}

AUC

P
value
^{c}

AUC

P
value
^{c}

AUC

P
value
^{c}

AUC

P
value
^{c}


Age, log Gail RR

0.6646

0.0019

0.839
 
0.5475

0.966

0.6748

0.470

0.6654

0.373

0.7243

0.495

Age, BMI

0.6845

0.3649

0.210
 
0.5775

0.619

0.6914

0.613

0.6826

0.317

0.7456

0.653

Age, log SNP RR

0.6848

0.3134

0.197
 
0.6068

0.445

0.6917

0.508

0.6890

0.153

0.7385

0.836

Age, BMI, log SNP RR

0.7007

0.9297

0.061
 
0.6258

0.337

0.7086

0.276

0.7078

0.060

0.7527

0.661

Gail factors^{e}

0.7144

0.3586

0.044

Reference

0.5488

0.123

0.7115

0.267

0.7390

0.019

0.7256

0.925

Gail factors, BMI

0.7279

0.7646

0.014

0.341

0.6964

0.072

0.7272

0.167

0.7463

0.011

0.7485

0.602

Gail factors, BMI, log SNP RR

0.7377

0.1924

0.007

0.212

0.7242

0.026

0.7356

0.116

0.7518

0.007

0.7719

0.442


^{a}AUC, Area under the receiver operating characteristic curve; BIRADS, Breast ImagingReporting and Data System; BMI, Body mass index; RR, Relative risk; SNP, Singlenucleotide polymorphism. ^{b}
Pvalue derived from HosmerLemeshow goodnessoffit (GOF) test. ^{c}
Pvalue derived from DeLong test compared to a model with age only. ^{d}
Pvalue derived from DeLong test compared to reference model. ^{e}Gail factors include age, race/ethnicity, age at menarche, age at first live birth, firstdegree family history of breast cancer, breast biopsy and atypical hyperplasia.